Analysis of the origin and properties of dental and bone marrow mesenchymal stem cells by using mice to label NC-derived and mesodermal cells

通过转基因小鼠，我们发现牙齿间充质主要由nc来源的细胞组成，而骨髓间充质有一半由nc来源的细胞和中胚层细胞以外的细胞组成。此外，一项集落形成单位-成纤维细胞（CFU-F）试验表明，牙髓中的CFU-F来自NC， BM来自NC和中胚层细胞。此外，我们发现牙间质支持B淋巴细胞和破骨细胞的分化。

By using transgenic mouse which enabled us to trace NC-derived or mesodermal cells, we showed that dental mesenchyme was composed of mainly NC-derived cells, whereas half of bone marrow(BM) mesenchyme was composed of cells other than NC-derived and mesodermal cells. Furthremore, a colony-forming unit-fibroblast(CFU-F) assay indicated that CFU-Fs in the dental pulp are derived from NC, and BM are derived from both NC and mesodermal cells. Furthermore, we showed that dental mesenchyme supported the differentiation of B lymphocytes and osteoclasts.