Functional architectonics of glyco-biomaterials designed via cellulosic nano-assemblers

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Nonaqueous biocatalysis and vectorial sugar-chain immobilization techniques that we successfully developed in this project allowed to functionally design various glyco-biointerfaces with controlled nanostructures of bioactive oligosaccharides via cellulosic nano-assemblers obtained from wood. Cellular morphology, physiological activation and immunological responses through glyco-receptor mediated signaling strongly depended on the combination and nanostructures of plural oligosaccharides, eventually revealing the possibility of the direct stimulation to cultured cells in contact with the biointerfaces. A pioneering research "Glyco-nanoarchitectonics" will open up a new phase for research and developments of new-concept glyco-biomaterials in medical and cell engineering fields.