Functional architectonics of glyco-biomaterials designed via cellulosic nano-assemblers

我们在本项目中成功开发的非水生物催化和载体糖链固定化技术使我们能够通过从木材中获得的纤维素纳米组装物来设计各种具有可控纳米结构的生物活性低聚糖的糖基生物界面。通过糖受体介导的信号转导的细胞形态、生理激活和免疫反应强烈依赖于多个寡糖的结合和纳米结构，最终揭示了直接刺激接触生物界面的培养细胞的可能性。一项开创性的研究“糖纳米建筑学”将为医学和细胞工程领域的新概念糖生物材料的研究和开发开辟新的阶段。

Nonaqueous biocatalysis and vectorial sugar-chain immobilization techniques that we successfully developed in this project allowed to functionally design various glyco-biointerfaces with controlled nanostructures of bioactive oligosaccharides via cellulosic nano-assemblers obtained from wood. Cellular morphology, physiological activation and immunological responses through glyco-receptor mediated signaling strongly depended on the combination and nanostructures of plural oligosaccharides, eventually revealing the possibility of the direct stimulation to cultured cells in contact with the biointerfaces. A pioneering research "Glyco-nanoarchitectonics" will open up a new phase for research and developments of new-concept glyco-biomaterials in medical and cell engineering fields.