Development of in vivo i ncubator having an ab i I i ty to enhance both the recruitment and the expansion of stem cells as a tool for basic medical researches

开发体内培养箱，能够增强干细胞的招募和扩增，作为基础医学研究的工具

• 批准号: 21680042
• 负责人: YAMAMOTO Masaya
• 金额: $ 12.98万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21680042/
• 关键词: 幹細胞; 人工ニッチ核酸アプタマー; 核酸アプタマー; 細胞培養基材; 細胞培養技術; 人工ニッチ

Recently many researches have demonstrated the importance of stem cells with a high potential of proliferation and differentiation to realize cell therapy and regenerative medicine. To this end, new technologies and methodologies to recruit and expand stem cells in the body have been developed to accelerate basic researches on cell therapy and regenerative medicine. In particular, both the controlled release of chemoattractant proteins and the immobilization of growth用romoting proteins for stem cells have been investigated.

Recently many researches have demonstrated the importance of stem cells with a high potential of proliferation and differentiation to realize cell therapy and regenerative medicine. To this end, new technologies and methodologies to recruit and expand stem cells in the body have been developed to accelerate basic researches on cell therapy and regenerative medicine. In particular, both the controlled release of chemoattractant proteins and the immobilization of growth romoting proteins for stem cells have been investigated.

项目成果

細胞培養基材としての高分子ハイドロゲルの設計

聚合物水凝胶作为细胞培养基质的设计

• 发表时间: 2010
• 作者: 山本雅哉;林健太朗;村上裕子;稲生佳菜子;田畑泰彦
• 通讯作者: 田畑泰彦

Generation of type I collagen gradient in polyacrylamide hydro gels by a simple diffusion-controlled hydrolysis of amide groups

通过酰胺基团的简单扩散控制水解在聚丙烯酰胺水凝胶中生成 I 型胶原梯度

• DOI: 10.3390/ma3042393
• 发表时间: 2010
• 期刊: Materials
• 影响因子: 3.4
• 作者: M. Yamamoto;K. Yanase;Y. Tabata
• 通讯作者: Y. Tabata

Orientation-regulated immobilization of Notch ligand on cell substrates for ex vivo proliferation of a cell population containing hematopoietic stem cell

Notch配体定向调节固定在细胞基质上，用于含有造血干细胞的细胞群的离体增殖

• 发表时间: 2011
• 作者: Toda;H.;Yamamoto;M.;Tabata;Y.
• 通讯作者: Y.

再生医療のためのバイオマテリアル.日本材料学会

日本材料学会再生医学生物材料。

• 发表时间: 2011
• 作者: H. Sakamoto;T. Arii;M. Kawata;松井翼;Kubo K,Ikebukuro T;山本雅哉
• 通讯作者: 山本雅哉

細胞培養基材としての糖応答性水可溶化ハイドロゲルの作製

作为细胞培养基质的糖响应性水溶性水凝胶的制备

• 发表时间: 2011
• 作者: 稲生佳菜子;山本雅哉;田畑泰彦
• 通讯作者: 田畑泰彦