Genome-wide association studies in world class athletes

本研究旨在确定肯尼亚、牙买加、美国和日本世界级运动员中与优秀短跑/力量和/或耐力运动员状态相关的遗传多态性。我们发现，线粒体单倍型组与肯尼亚和日本运动员的优秀耐力运动员状态相关，还发现线粒体单倍型组与日本和非洲裔美国运动员的短跑/力量运动员状态之间存在有趣的关联，并与日本非运动员个体的肌肉力量有关。在牙买加和日本的优秀短跑/力量和耐力运动员中进行了全基因组关联研究（GWAS）。在日本运动员中，使用卡方检验比较短跑/力量和耐力运动员之间的每个多态性的频率。在750，000个基因多态性中，5个等位基因频率在组间差异显著（p<0.00001）。

The present study was to identify genetic polymorphisms which were associated with elite sprint/power and/or endurance athlete status in world class athletes of Kenya, Jamaica, US, and Japan. We found that mitochondrial haplogroups were associated with elite endurance athlete status in elite Kenyan and Japanese athletes, also found intriguing associations between mitochondrial haplogroups with sprint/power athlete status in elite Japanese and African-American athletes, and with muscle power in Japanese non-athlete individuals. A genome-wide association studies(GWAS) was performed in elite sprint/power and endurance athletes of Jamaican and Japanese. In Japanese athletes, frequencies of each polymorphism between sprint/power and endurance athletes were compared using Chi-square tests. Among 750, 000 genetic polymorphisms, 5 allele frequencies differed significantly(p<0.00001) between groups.