Molecular behavior in non-equilibrium and asymmetric domains formed in supported planar lipid bilayers

点击翻译按钮获取中文摘要

Molecular diffusion behavior in supported planar lipid bilayers at submicron regions were observed in situ, and controlled using nanostructures on solid substrates. I constructed a fluorescence microscope for single molecule tracking at the spatiotemporal order over millisecond / 100 nm to second/μm, and achieved the single molecule tracking on opaque substrates and high-refractive substrates such as silicon and titanium dioxide. In situ observation of lipid diffusion at 2000 fps to 33 fps revealed that surface nanostructures on the substrates induced anomalous diffusion in the supported lipid bilayer.