Central molecular mechanism of autonomic actions by hormone derived from adipose tissue
Central molecular mechanism of autonomic actions by hormone derived from adipose tissue
批准号:
21689008
负责人:
TANIDA Mamoru
金额:
$12.31万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (A)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
我们强烈注意到代谢综合征在日本的死亡率很高。在此基础上,我们利用动物自主神经记录系统,研究了瘦素和脂联素这两种作用于大脑并在摄食和体内平衡中发挥重要作用的物质。我们新发现瘦素或脂联素在自主调节中的中枢机制,希望将其应用于新的药物研究。
英文摘要
We strongly noted metabolic syndrome having a high mortality in Japan. Then, in present study, we examined leptin and adiponectin which act in the brain and play an important role in feeding and homeostasis with using animal autonomic recording system. We newly showed that central mechanism of leptin or adiponectn in autonomic regulation, hoping it will be applied to new drag research.
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Effect of an intraduodenal injection of fat on the activities of the adrenal efferent ympathetic nerve and the gastric efferent parasympathetic nerve in urethane-anesthetized rats.
十二指肠内注射脂肪对乌拉坦麻醉大鼠肾上腺传出交感神经和胃传出副交感神经活动的影响。
DOI:
--
发表时间:
2010
期刊:
Neuroscience Research
影响因子:
2.9
作者:
[Matsumura S, Eguchi A, Kitabayashi N, Tanida M, Shen J, Horii Y, Nagai K, Tsuzuki S, Inoue K, Fushiki T.]
通讯作者:
Fushiki T.
PACAPによる自律神経作用
PACAP 引起的自主神经效应
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[谷田守, 新谷紀人, 畑中道賢, 橋本均, 馬場明道]
通讯作者:
馬場明道
Brain insulin resistance accelerates As fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes
通过诱导 GM1 神经节苷脂在突触前膜中聚集,大脑胰岛素抵抗加速纤维化形成
DOI:
--
发表时间:
2012
期刊:
Journal of Neurochemistry
影响因子:
4.7
作者:
[Yamamoto N, Matsubara T, Sobue K, Tanida M, Kasahara R, Naruse K, Taniura H, Sato T, Suzuki K]
通讯作者:
Suzuki K
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[J.Shen, J-F.Yao, M.Tanida, Y.Horii, K.Nagai]
通讯作者:
K.Nagai
DOI:
10.12938/bifidus.30.99
发表时间:
2011-01-01
期刊:
Bioscience and microflora
影响因子:
--
作者:
[Tanida, Mamoru, Nagai, Katsuya]
通讯作者:
Nagai, Katsuya
共 36 条
Analysis of autonommic regulation by hormone secreted from skeletal muscle and significance in metablic symdrome improvement
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批准号:20H04133
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.73万
-
财政年份:2020
-
负责人:TANIDA Mamoru
-
依托单位:
Mechanism of nesfatin-1-induced stimulation of sympathetic nerve in white adipose tissue
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批准号:16K09767
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
-
财政年份:2016
-
负责人:TANIDA Mamoru
-
依托单位:
Regulations of Hepatic and pancreatic autonomic nerves by leptin and application to improvement of glucose metabolism
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批准号:26870672
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.58万
-
财政年份:2014
-
负责人:TANIDA Mamoru
-
依托单位:
海外基金