Transcription factor complex network and application in gene therapyfor patients with male infertility

转录因子复合体网络及其在男性不育症基因治疗中的应用

• 批准号: 21689043
• 负责人: KOJIMA Yoshiyuki
• 金额: $ 16.97万
• 依托单位: Fukushima Medical University (2012)Nagoya City University (2009-2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21689043/
• 关键词: 男性不妊症; 転写因子; 遺伝子導入; 男性不妊; ネットワーク; 男子不妊症

Assisted reproductive technology is the most appropriate management if a natural pregnancy fails to occur, and this is increasingly used in the treatment of both male and female infertility. However, fertilization is better in vivo than in vitro for male infertility. Clinically, testicular gene therapy may be useful to treat male infertility in the future because it is possible to promote spermatogenesis in male infertility patient. In this study, I tried to perform basic research to realize the gene therapy for male infertility. Although more genetic information about the molecular basis of spermatogenesis will be needed to apply gene therapy for male infertility, these informations may lead to new strategies for the clinical management and gene therapy will provides great benefits for the patients with male infertility in the future.

如果自然怀孕失败，辅助生殖技术是最适当的管理，这越来越多地用于治疗男性和女性不育症。然而，对于男性不育症，体内受精比体外受精更好。临床上，睾丸基因治疗有可能促进男性不育患者的精子发生，因此，睾丸基因治疗在男性不育症的治疗中有着广阔的应用前景。本研究旨在为实现男性不育症的基因治疗做基础研究。尽管对精子发生的分子基础还需要更多的基因信息才能应用于男性不育的基因治疗，但这些信息可能会为临床治疗提供新的策略，基因治疗将为未来的男性不育患者提供巨大的利益。

项目成果

Clinical Features and Testicular Morphology in Patients with Kallmann Syndrome

• DOI: 10.1016/j.urology.2011.10.032
• 发表时间: 2012-03-01
• 期刊: UROLOGY
• 影响因子: 2.1
• 作者: Nishio, Hidenori;Mizuno, Kentaro;Hayashi, Yutaro
• 通讯作者: Hayashi, Yutaro

Findings of MR fat-suppressed T2-weighted and diffusion-weighted imaging in the diagnosis of nonpalpable testes

MR 脂肪抑制 T2 加权和扩散加权成像在不可触及睾丸诊断中的发现

• 发表时间: 2011
• 期刊: BJU int
• 影响因子: 4.5
• 作者: Kato T;Kojima Y;Sasaki S;Kohri K
• 通讯作者: Kohri K

Gene therapy for male infertility; potential and limitation. Lejeune T and Delvaux (eds). In: Human spermatozoa: Maturation, Capacitation and Abnormalities.

男性不育症的基因治疗；

• 发表时间: 2010
• 作者: Kojima Y;Sasaki S;Kohri K.
• 通讯作者: Kohri K.

Therapeutic potential of gene transfer to testis; Myth or reality? Kang C (eds).In: Gene Therapy Application.

睾丸基因转移的治疗潜力；

• 发表时间: 2011
• 作者: Kojima Y;Sasaki S;Kohri K.
• 通讯作者: Kohri K.

Intratesticular pressure after testicular torsion as a predictor of subsequent spermatogenesis-an animal study-

睾丸扭转后睾丸内压力作为随后精子发生的预测因子——一项动物研究——

• 发表时间: 2012
• 期刊: BJU int
• 影响因子: 4.5
• 作者: Moritoki Y;Kojima Y;Kohri K
• 通讯作者: Kohri K