Analysis of a cardiac mathematical model for suppressing alternans

电交替是在心脏细胞的动作电位中一次又一次地改变幅度。在许多临床研究中，它与室性心律失常有关。在本研究中，我们构建了一个简单的心脏系统网络模型。利用这个模型，我们阐明了两个参数(胞外室内钠离子的电导和钾离子的自由浓度)对交替菌的产生起着关键作用。这一结果表明，如果肌肉细胞有一些问题，如通道病，那么就有很大的风险发生交替。

Electrical alternans is alternating amplitude from beat to beat in the action potential for the cardiac cell. It has been associated with ventricular arrhythmias in many clinical studies. In this study, we construct a simple network model of the heart system. Using this model, we clarify that two parameters (the conductance of the sodium ion and free concentration of the potassium ion in the extracellular compartment) play key roles of generating alternans. This result indicates that if the muscle cell has some problems such as channelopathies, then there is great risk of occurring alternans.