Developmental analysis of the neural activity in the left and right hemispheres using zebrafish

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We focused on the zebrafish habenular circuit showing the left-right asymmetry in the projection pattern to study the difference in neural connectivity and its activity between left and right hemispheres. Through the analyses, we were able to 1) visualize the difference in the activity of the cells in the left and right habenula with calcium imaging, 2) identify the fish homologue of mammalian medial and lateral habenulae by the hodological and gene expression analyses and 3) identify the output pathway of the interpeduncular nucleus which receives asymmetric projection from the dorsal habenula.