Genetic identification of the habenular pathway regulating the monoamines metabolism in the brain

调节大脑单胺代谢的缰核途径的遗传鉴定

• 批准号: 24700350
• 负责人: AIZAWA Hidenori
• 金额: $ 2.83万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24700350/
• 关键词: 手綱核; モノアミン; アストロサイト; グリア; ドーパミン; セロトニン; 神経回路

Habenular subnuclei in the rodents were characterized by the heterogeneity of the neurons in expression of marker genes for glutamatergic, cholinergic and substance P-ergic transmission and monoaminergic receptors. Tamoxifen injection to Dbx1CreERT2/+ knock-in mouse line before (embryonic days 12-16) and after birth (postnatal days 0-3) resulted in the ubiquitous labeling of the cells in the adult forebrain and specific labeling of the astrocytes in the adult habenula, respectively. Electrophysiological study revealed that the habenula lesion elicited the impairment of the hippocampal theta oscillation, which was dependent upon the intact serotonergic raphe in the brain stem. These results suggested that the habenula affected the diverse brain activity via modulation of neuronal activity in the monoaminergic neurons.

在啮齿类动物的缰核亚核的特点是异质性的神经元的标记基因的表达的多巴胺能，胆碱能和P物质能的传输和单胺能受体。在出生前（胚胎12-16天）和出生后（出生后0-3天）注射他莫昔芬到Dbx 1CreERT 2/+敲入小鼠系导致成体前脑中细胞的普遍标记和成体缰核中星形胶质细胞的特异性标记。电生理研究表明，缰核损伤引起海马θ振荡的损害，这种损害依赖于脑干中完整的突触能中缝核。这些结果表明，缰核通过调节单胺能神经元的神经元活动而影响多种脑活动。

项目成果

Activation of the lateral habenula under the acute and chronic stress

急性和慢性应激下外侧缰核的激活

• 发表时间: 2013
• 作者: Aizawa H;Kobayashi M;Tanaka S;Fukai T;Okamoto H.;相澤秀紀;崖万鵬,田中光一,相津秀紀
• 通讯作者: 崖万鵬,田中光一,相津秀紀

うつ病様行動における手綱核の役割

缰核在抑郁样行为中的作用

• 发表时间: 2013
• 作者: Aizawa H;Kobayashi M;Tanaka S;Fukai T;Okamoto H.;相澤秀紀;崖万鵬,田中光一,相津秀紀;相津秀紀;崖万鵬,孫偉楠,田中光一,相津秀紀
• 通讯作者: 崖万鵬,孫偉楠,田中光一,相津秀紀

Activation of habenula neurons in the social avoidance behavior after chronic social stress

慢性社会应激后社交回避行为中缰核神经元的激活

• 发表时间: 2012
• 作者: 崔万鵬;孫偉楠;田中光一;相澤秀紀;崖万鵬,田中光一,相津秀紀
• 通讯作者: 崖万鵬,田中光一,相津秀紀

Temporally-regulated neurogenesis and gliogenesis in the mouse habenula

小鼠缰核中时间调节的神经发生和胶质细胞发生

• 发表时间: 2012
• 作者: 崔万鵬;孫偉楠;田中光一;相澤秀紀;崖万鵬,田中光一,相津秀紀;相津秀紀,崖万鵬,田中光一
• 通讯作者: 相津秀紀,崖万鵬,田中光一

Hyperactivation of the habenula as a link between depression and sleep disturbance.

• DOI: 10.3389/fnhum.2013.00826
• 发表时间: 2013-12-10
• 期刊: Frontiers in human neuroscience
• 影响因子: 2.9
• 作者: Aizawa H;Cui W;Tanaka K;Okamoto H
• 通讯作者: Okamoto H