Analysis plasticity of monoaminergic and cholinergic neurons in nalcoleptic mice

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I examined monoaminergic neuronal activities of narcoleptic mice (orexin neuron deficiency mice). Firing frequency of Locus ceruleus noradrenergic neuron was increased in narcoleptic mice by in vivo extracellular recording during wakefulness and slow wave sleep. In vitro patch clamp recording, IPSC of noradrenergic neuron was reduced in narcoleptic mice. This reduction might be results the increasing of firing frequency of noradrenergic neuron in narcoleptic mice.