Physiological analysis of synaptic tagging

依赖活动的突触可塑性被广泛接受，为学习和记忆提供细胞基础。突触标记和捕获可能参与活性依赖的突触可塑性，因为它区分了突触标记的局部机制和负责合成可塑性相关蛋白的细胞范围的机制。我发现一种可塑性相关的丝氨酸蛋白酶，神经蛋白酶，在LTP的基础和顶端树突状输入参与标签设置过程。Neuropsin通过整合素β1和CaMKII信号参与长时程增强过程中的突触标记和交叉标记。

Activity-dependent synaptic plasticity is widely accepted to provide a cellular basis for learning and memory. Synaptic tagging and capture could be involved in activity-dependent synaptic plasticity, because it distinguishes between local mechanisms of synaptic tags and cell-wide mechanisms that are responsible for the synthesis of plasticity-related proteins. I found that a plasticity related serine protease, neuropsin, is involved in the tag-setting process during LTP at basal and apical dendritic inputs. Neuropsin is involved in synaptic tagging and cross-tagging during LTP at apical dendritic inputs via integrin beta-1 and CaMKII signaling.