Physiological analysis of process specific synaptic tagging

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Activity-dependent synaptic plasticity is widely accepted to provide a cellular basis for learning and memory. Synaptic associativity could be involvedin activity-dependent synaptic plasticity, because it distinguishes between local mechanisms of synaptic tags and cell-wide mechanisms that are responsible for the synthesis of plasticity-related proteins. We report that a plasticity-related serine protease, neuropsin, is involved in the tag-setting process during long-term potentiation (LTP) at basal and apical dendritic inputs. Neuropsin is involved in synaptic associativity during LTP at apical dendritic inputs via integrin β1 and CaMKII signalling. Thus, neuropsin is a candidate molecule for LTP-specific tag-setting and could regulate the transformation of early to late LTP during synaptic associativity. These findings may provide the understanding of the regulation of synaptic associativity as complex information-processing systems.