The propagation mechanism of Semaphorin3A signaling in neurons

神经元是高度极化的细胞，有轴突、树突和细胞体。这些亚细胞隔间需要相互通信。例如，在远端轴突中接收到的信号经过很长的距离到达细胞体和/或树突。在本研究中，我发现了轴突导向分子在轴突生长锥接收到的信号向细胞体和树突传递的新机制。我进一步发现，这个新的信号调节树突的形态和成熟。因此，我提出了在远端轴突接收到的轴突引导信号通过这种新的信号传播机制同时调节树突发育的模型。

Neurons are highly polarized cells with axon, dendrites, and cell body. These subcellular compartments need to communicate with each other. For example, signals received in distal axon travel long distances to reach the cell body and/or dendrites. In present study, I identified novel mechanism that the signal elicited by axon guidance molecule which is received at axonal growth cone, is transmitted towards cell body and dendrites. I further found that this novel signaling mediates dendritic morphology and maturation. Therefore I propose the model that the axon guidance signal which is received at distal axon simultaneously regulates dendritic development by this novel signal propagation mechanism.