The propagation mechanism of Semaphorin3A signaling in neurons

神经元是具有轴突、树突和胞体的高度极化的细胞。这些亚细胞区室需要相互交流。例如，在远端轴突中接收的信号传播很长距离以到达细胞体和/或树突。在本研究中，我发现了一种新的机制，即由轴突导向分子引发的信号在轴突生长锥处被接收，并向胞体和树突传递。我进一步发现，这种新的信号介导树突形态和成熟。因此，我提出了一个模型，即轴突远端接受的轴突引导信号通过这种新的信号传播机制同时调节树突的发育。

Neurons are highly polarized cells with axon, dendrites, and cell body. These subcellular compartments need to communicate with each other. For example, signals received in distal axon travel long distances to reach the cell body and/or dendrites. In present study, I identified novel mechanism that the signal elicited by axon guidance molecule which is received at axonal growth cone, is transmitted towards cell body and dendrites. I further found that this novel signaling mediates dendritic morphology and maturation. Therefore I propose the model that the axon guidance signal which is received at distal axon simultaneously regulates dendritic development by this novel signal propagation mechanism.