The propagation mechanism of Semaphorin3A signaling in neurons

Semaphorin3A信号在神经元中的传播机制

• 批准号: 21700411
• 负责人: YAMASHITA Naoya
• 金额: $ 2.58万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700411/
• 关键词: セマフォリン; 神経栄養因子; シグナル伝播; シグナル伝搬

Neurons are highly polarized cells with axon, dendrites, and cell body. These subcellular compartments need to communicate with each other. For example, signals received in distal axon travel long distances to reach the cell body and/or dendrites. In present study, I identified novel mechanism that the signal elicited by axon guidance molecule which is received at axonal growth cone, is transmitted towards cell body and dendrites. I further found that this novel signaling mediates dendritic morphology and maturation. Therefore I propose the model that the axon guidance signal which is received at distal axon simultaneously regulates dendritic development by this novel signal propagation mechanism.

神经元是高度极化的细胞，有轴突、树突和细胞体。这些亚细胞隔间需要相互通信。例如，在远端轴突中接收到的信号经过很长的距离到达细胞体和/或树突。在本研究中，我发现了轴突导向分子在轴突生长锥接收到的信号向细胞体和树突传递的新机制。我进一步发现，这个新的信号调节树突的形态和成熟。因此，我提出了在远端轴突接收到的轴突引导信号通过这种新的信号传播机制同时调节树突发育的模型。

项目成果

軸索ガイダンスおよびシナプス形成とCdk5

轴突引导和突触形成以及 Cdk5

• 发表时间: 2009
• 期刊: 蛋白質核酸酵素 54
• 作者: 山下直也;中村史雄;五嶋良郎
• 通讯作者: 五嶋良郎

Structural basis for semaphorin signalling through the plexin receptor

• DOI: 10.1038/nature09473
• 发表时间: 2010-10-28
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Nogi, Terukazu;Yasui, Norihisa;Takagi, Junichi
• 通讯作者: Takagi, Junichi

Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice

• DOI: 10.1002/cne.22125
• 发表时间: 2009-10
• 期刊: Journal of Comparative Neurology
• 影响因子: 2.5
• 作者: F. Nakamura;Kozue Ugajin;N. Yamashita;Takako Okada;Yutaka Uchida;M. Taniguchi;T. Ohshima;Y. Goshima

Comprehensive behavioral analysis of the crmp1 knockout mice

CRMP1敲除小鼠的综合行为分析

• 发表时间: 2009
• 作者: Yamashita N;Takao K;Miyakawa T;Goshima Y
• 通讯作者: Goshima Y

Computational Analysis of the Effects of Antineoplastic Agents on Axonal Transport

抗肿瘤药物对轴突运输影响的计算分析

• DOI: 10.1254/jphs.09352fp
• 发表时间: 2010
• 期刊: Journal of Pharmacological Sciences
• 影响因子: 3.5
• 作者: Goshima Y;Usui H;Shiozawa T;Hida T;Kuraoka S;Takeshita S;Yamashita N;Ichikawa Y;Kamiya Y;Gotoh T;Gotoh T.
• 通讯作者: Gotoh T.