Analysis of the reactivation of food-odor evoked activity in the olfactory cortex

嗅觉皮层食物气味诱发活动的重新激活分析

• 批准号: 21700429
• 负责人: MANABE Hiroyuki
• 金额: $ 2.33万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700429/
• 关键词: 神経科学; 嗅覚; 電気生理; 睡眠; 嗅皮質; 鋭波; sharp wave

The olfactory cortex is functionally isolated from the external odor world during slow-wave sleep. However, the neuronal activity pattern in the olfactory cortex and its functional role during slow-wave sleep were not well understood. Here, I demonstrated in freely behaving rats that the anterior piriform cortex repeatedly generated sharp waves accompanied by synchronized discharges of numerous cortical neurons during slow-wave sleep. The olfactory cortex sharp waves drove synchronized top-down inputs to the olfactory bulb. The olfactory cortex sharp waves may represent the reactivation of the neuronal activation pattern during preceding waking period and contribute to the memory consolidation process in the olfactory cortex.

在慢波睡眠期间，嗅觉皮层在功能上与外部气味世界隔离。然而，嗅觉皮层的神经元活动模式及其在慢波睡眠中的功能作用还没有得到很好的理解。在这里，我证明了在自由行为的大鼠中，前梨状皮质在慢波睡眠期间反复产生尖锐的波，伴随着许多皮质神经元的同步放电。嗅觉皮层的尖波驱动同步的自上而下的输入到嗅球。嗅觉皮层尖波可能代表了清醒前神经元激活模式的再激活，并参与了嗅觉皮层的记忆巩固过程。

项目成果

Olfactory cortex sharp waves during slow-wave sleep

慢波睡眠期间嗅觉皮层锐波

• 发表时间: 2010
• 作者: Hiroyuki Manabe;Ikue Kusumoto-Yoshida;Mizuho Ota;Kensaku Mori
• 通讯作者: Kensaku Mori

Olfactory cortex generates sharp waves that drive synchronized inputs to the granule cells in the olfactory bulb during slow-wave sleep

嗅觉皮层产生锐波，在慢波睡眠期间驱动同步输入到嗅球中的颗粒细胞

• 发表时间: 2010
• 作者: Hiroyuki Manabe;Ikue Kusumoto-Yoshida;Mizuho Ota;Kensaku Mori
• 通讯作者: Kensaku Mori

Neuronal circuits responsible for the generation of olfactory cortex and olfactory bulb sharp waves during slow-wave sleep

慢波睡眠期间负责产生嗅觉皮层和嗅球尖波的神经元回路

• 发表时间: 2010
• 作者: Hiroyuki Manabe;Ikue Kusumoto-Yoshida;Mizuho Ota;Kensaku Mori
• 通讯作者: Kensaku Mori

Olfactory cortex generates sharp waves that drive synchronized input to the granule cells in the olfactory bulb during slow-wave sleep

嗅觉皮层产生锐波，在慢波睡眠期间驱动同步输入到嗅球中的颗粒细胞

• 发表时间: 2010
• 作者: Hiroyuki Manabe;Ikue Kusumoto-Yoshida;Mizuho Ota;Kensaku Mori;松野元美;眞部寛之
• 通讯作者: 眞部寛之

Olfactory Cortex Generates Synchronized Top-Down Inputs to the Olfactory Bulb during Slow-Wave Sleep

• DOI: 10.1523/jneurosci.6578-10.2011
• 发表时间: 2011-06-01
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Manabe, Hiroyuki;Kusumoto-Yoshida, Ikue;Mori, Kensaku
• 通讯作者: Mori, Kensaku