Revealing visual representation mechanism of objects by multiple functional modules

我与东京大学铃木博士领导的一个研究小组合作，开发了一种用于皮层脑电记录的网状电极阵列，其中有微电极和光纤等小探针的开口供其通过。我将这个ECoG阵列和一个穿透性微电极阵列一起植入猕猴的IT皮质，并在猴子执行注视任务时同时记录视觉诱发的皮质电位和单位活动。解码分析表明，面孔、面孔和物种等刺激类别的分类可以在ECoG和多点单位记录中以相似的操作水平进行。这一结果还表明，术后多个细微探头从ECoG窗进入大脑皮层是可行的，而不会对皮质功能造成重大损害。这一结果表明，利用个体遗传学工具，如通道-视紫红质，同时进行多部位刺激，以及对灵长类动物视觉皮质进行多部位电生理记录，是一种有前途的应用。

I developed a mesh-shaped electrode array for electrocorticogram recording with openings for small probes, such as microelectrode and optical fiber, to pass through in collaboration with a group lead by Dr. Suzuki at University of Tokyo. I implanted this ECoG array together with a penetrating microelectrode array into the macaque IT cortex, and simultaneous recorded visually evoked cortical potential and unit activities while the monkey performed a fixation task. Decoding analysis showed that classification of the stimulus category, such as face, facial view and species could be performed with similar performance level from both ECoG and multi-site unit recording. This result also indicated that postoperative penetration of multiple fine probes into the cerebral cortex from ECoG windows applicable without major damage to the cortical function. This result suggests promising application to simultaneous conduction of multisite stimulation with ontogenetics tools, such as channel-rhodopsin, and multi-site electrophysiological recording from behaving primate visual cortices.