Revealing visual representation mechanism of objects by multiple functional modules

我与东京大学铃木博士领导的一个小组合作，开发了一种网状电极阵列，用于皮质电图记录，上面有小探针的开口，比如微电极和光纤，可以通过。我将这个ECoG阵列和穿透性微电极阵列一起植入猕猴的IT皮层，同时记录猴子执行固定任务时视觉诱发的皮层电位和单位活动。解码分析表明，脑电图和多点单元记录均能以相近的表现水平完成人脸、面部视图和物种等刺激类别的分类。这一结果也表明，术后从ECoG窗口向大脑皮层插入多个细探针是可行的，不会对皮质功能造成重大损害。这一结果表明，利用个体遗传学工具（如通道视紫红质）和灵长类动物行为视觉皮层的多位点电生理记录来同时传导多位点刺激是有希望的。

I developed a mesh-shaped electrode array for electrocorticogram recording with openings for small probes, such as microelectrode and optical fiber, to pass through in collaboration with a group lead by Dr. Suzuki at University of Tokyo. I implanted this ECoG array together with a penetrating microelectrode array into the macaque IT cortex, and simultaneous recorded visually evoked cortical potential and unit activities while the monkey performed a fixation task. Decoding analysis showed that classification of the stimulus category, such as face, facial view and species could be performed with similar performance level from both ECoG and multi-site unit recording. This result also indicated that postoperative penetration of multiple fine probes into the cerebral cortex from ECoG windows applicable without major damage to the cortical function. This result suggests promising application to simultaneous conduction of multisite stimulation with ontogenetics tools, such as channel-rhodopsin, and multi-site electrophysiological recording from behaving primate visual cortices.