Fundamental Study for Development of An Engineering Model of Remodeling Mechanism of Blood Vessel Walls in Response to Mechanical Environment

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To understand quantitative relationship between hemodynamic environment and remodeling of vessel walls, I investigated functional changes in vascular endothelial cells (ECs) exposed to fluid shear stress conditions. The results indicate that EC activity in wall degradation is suppressed under a physiological shear stress condition and higher shear stress may enhance the activity in degradation of vessel walls. Furthermore, I found that spatial gradient of shear stress also has an impact on ECs functions, which may be crucial to formation of vascular diseases.