Effects of localized compliance on gas dispersion in small airways

在呼吸过程中，气流是由肺变形引起的，因此进行了气体交换和质量输送。在本研究中，为了了解深肺的呼吸生理，我们使用同步辐射ct观察和分析气道小变形，并数值模拟肺泡血流。结果表明，较小气道的气道变形较大，直径较功能残余容量增大约100%。仅哮喘小气道形态学改变较低。在数值模拟中，气道变形促进了气体的扩散。

During respiration, airflow is induced by lung deformation, and so gas exchange and mass transport is performed. In this study, to understand the respiratory physiology in deep lung, we observed and analyzed small airway deformation using synchrotron radiation-CT and simulated alveolar flow numerically. As the results, the airway deformation was larger in smaller airways, and the diameter increased by about 100% compared with the values at functional residual capacity. And, the morphometric change was lower of only asthmatic small airways. In numerical simulation of gas dispersion, it was promoted by airway deformation.