Alveolar kinematics and gas exchange mechanism in chronic pulmonarydiseases

在这项研究中，我们分析了健康和慢性阻塞性肺疾病（COPD）的腺泡运动学同步加速器基于计算机断层扫描，并在肺腺泡中的质量输运的数值模拟。在准静态充气状态下，健康小鼠气道直径在吸气早期即增大。COPD小鼠的增加率小于健康小鼠。我们研究了健康和COPD腺泡模型的气流同步加速CT重建。COPD组小鼠不仅呼吸速率变小，而且吸气与呼气流速之差也变小，提示COPD组小鼠的气体交换能力可能变差。

In this study, we analyzed the acinar kinematics of healthy and chronic obstructive pulmonary diseases (COPD) using synchrotron based computed tomography, and numerical simulation of mass transport in pulmonary acinus. Under quasi-static inflation, in healthy mice, the duct diameter increased at early phase of inspiration. The increase rate in COPD mice was smaller than healthy mice. We investigated the airflow in healthy and COPD acinar model reconstructed from synchrotron CT. Not only the velocity but also the difference between inspiratory and expiratory flow were smaller in COPD mice than healthy mice, indicating that the gasexchange performance might become worse in COPD.