Discovery of the function of lipophilic ligand on metabolic disease

本研究的目的是发现脂溶性配体受体在代谢紊乱相关器官如脂肪组织、骨骼肌、肝脏和心脏中的功能。GPR 30是雌激素的膜受体，在脂肪组织、骨骼肌、肝脏、原代心肌细胞和心肌成纤维细胞中表达，在心肌梗死中检测到。给予17β-雌二醇可诱导心肌细胞和肌成纤维细胞上ERK的磷酸化。这些结果表明，雌激素在心脏中具有通过GPR 30的非基因组效应。

The aim of this study is the discovery of the function of lipophilic ligand receptors in metabolic disorder-related organ, such as adipose tissue, skeletal muscle, liver and heart. GPR30, membrane receptor of estrogen, was expressed in adipose tissue, skeletal muscle, liver, primary cardiac myocytes and cardiac myofibroblasts, which are detected in myocardial infarction. Administration of 17β-estradiol induced the phosphorylation of ERK on myocytes and myofibroblasts. These results suggest that estrogen possesses the non-genomic effect via GPR30 in heart.