Study for the mechanism in development of lifestyle-related disease by intake of dietary vegetable oil

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This study revealed that increase in plasma lipids was involved in a part of mechanism in the shortening of lifespan of stroke prone spontaneously hypertensive rats (SHRSP), one animal model of lifestyle-related disease, fed diet containing 10 w/w% canola oil. This increase, which was observed on and after the early intake period, was inhibited by the combined administration of clofibrate, a PPAR alpha agonist. Additionally, incidences of death and chronic nephropathy were attenuated by the administration. Further studies are needed to elucidate the mechanism of short lifespan induced by canola oil intake, involving the detailed mode of action of clofibrate.