Design of a bioreductively-activated fluorescent probe for tumor hypoxia imaging

建立了一种既能在试管中检测酶活性又能在细胞中检测酶活性的新型荧光探针的合理设计方法。例如，可以在生物还原条件下激活的荧光探针可以检测肿瘤缺氧。荧光探针在活细胞中的缺氧和有氧条件之间的荧光行为显示出明显的差异。

Rational design methodology of the novel fluorescent probe to detect the enzymatic activity not only in test tube but also in cell was developed. For example, the fluorescent probe which could be activated in the bioreductive condition can detect the tumor hypoxia. The fluorescent probe showed clear differences in fluorescence behavior between hypoxic and aerobic conditions in the live cell.