Elucidation of mechanisms of recognizing other's intention using newly developing in vivo connection imaging and electrophyisiology

利用新开发的体内连接成像和电生理学阐明识别他人意图的机制

• 批准号: 22300104
• 负责人: NORITAKA Ichinohe
• 金额: $ 11.98万
• 依托单位: National Center of Neurology and Psychiatry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300104/
• 关键词: ミラーニューロン; 模倣; 自閉症; 社会脳; 社会学習; 霊長類; 新世界ザル; 核家族; 顔認知; 大脳皮質; 皮質カラム; 機能構造連関

We investigated circuits for object recognition in macaque anterior (TE) and posterior inferotemporal cortex (TEO), using a two-step method with in vivo anatomical imaging. In step 1, red fluorescent tracer was injected into TE to reveal and Pre-target patches of feedforward neurons in TEO. In step 2, these were visualized on the cortical surface in vivo, and injected with green fluorescent tracer. Histological processing revealed that patches >500 μm from the injection site in TEO consisted of intermingled green TEO intrinsically projecting neurons and red TEO-to-TE neurons, with only few double-labeled neurons. In contrast, patches near the injection site in TEO contained many double-labeled neurons. Two parallel, spatially intermingled circuits are suggested: (1) TEO neurons having very local intrinsic collaterals and projection to TE (2) TEO neurons projecting more widely in the intrinsic network, but not to TE. These parallel systems might be specialized for, respectively, fast vs. highly processed signals.

我们使用带有体内解剖学成像的两步方法研究了猕猴前（TE）和后颞下皮皮层（TEO）的对象识别的电路。在步骤1中，将红色荧光示踪剂注入Te中，以揭示TEO中的前馈神经元的靶向和预先靶向斑块。在步骤2中，将它们在体内的皮质表面上可视化，并注入绿色荧光示踪剂。组织学处理表明，TEO注射部位的斑块>500μm，由绿色TEO固有地突出的神经元和红色TEO-TEO-TE-TE-TE神经元组成，只有少数双标记神经元。相比之下，TEO注射部位附近的斑块包含许多双标记神经元。提出了两个相似的空间相互混合的电路：（1）具有非常局部的内在综合膜和对TE（2）TEO神经元投影的TEO神经元在固有网络中投射更广泛，但对TE不广泛。这些平行系统可能分别专门用于快速和处理高度处理的信号。

项目成果

Pathway-specific utilization of synaptic zinc in the macaque ventral visual cortical areas.

• DOI: 10.1093/cercor/bhq028
• 发表时间: 2010-12
• 期刊: Cerebral cortex (New York, N.Y. : 1991)
• 作者: Ichinohe N;Matsushita A;Ohta K;Rockland KS
• 通讯作者: Rockland KS

Reciprocal Connectivity of Identified Color-Processing Modules in the Monkey Inferior Temporal Cortex

• DOI: 10.1093/cercor/bhq211
• 发表时间: 2011-06-01
• 期刊: CEREBRAL CORTEX
• 影响因子: 3.7
• 作者: Banno, Taku;Ichinohe, Noritaka;Komatsu, Hidehiko
• 通讯作者: Komatsu, Hidehiko

Neurotrophin-3 is involved in the formation of apical dendritic bundles in cortical layer 2 of the rat.

• DOI: 10.1093/cercor/bhp093
• 发表时间: 2010-01
• 期刊: Cerebral cortex (New York, N.Y. : 1991)
• 作者: Miyashita T;Wintzer M;Kurotani T;Konishi T;Ichinohe N;Rockland KS
• 通讯作者: Rockland KS

生体内線維連絡可視化法を用いた顔認知の研究

利用体内光纤通信可视化方法进行人脸识别的研究

• 发表时间: 2011
• 作者: Nawa H;Yamada K;一戸紀孝
• 通讯作者: 一戸紀孝

物体を認識する脳内神経伝達メカニズムを解明

阐明大脑中识别物体的神经传递机制