Elucidation of mechanisms of recognizing other's intention using newly developing in vivo connection imaging and electrophyisiology

利用新开发的体内连接成像和电生理学阐明识别他人意图的机制

• 批准号: 22300104
• 负责人: NORITAKA Ichinohe
• 金额: $ 11.98万
• 依托单位: National Center of Neurology and Psychiatry
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300104/
• 关键词: ミラーニューロン; 模倣; 自閉症; 社会脳; 社会学習; 霊長類; 新世界ザル; 核家族; 顔認知; 大脳皮質; 皮質カラム; 機能構造連関

We investigated circuits for object recognition in macaque anterior (TE) and posterior inferotemporal cortex (TEO), using a two-step method with in vivo anatomical imaging. In step 1, red fluorescent tracer was injected into TE to reveal and Pre-target patches of feedforward neurons in TEO. In step 2, these were visualized on the cortical surface in vivo, and injected with green fluorescent tracer. Histological processing revealed that patches >500 μm from the injection site in TEO consisted of intermingled green TEO intrinsically projecting neurons and red TEO-to-TE neurons, with only few double-labeled neurons. In contrast, patches near the injection site in TEO contained many double-labeled neurons. Two parallel, spatially intermingled circuits are suggested: (1) TEO neurons having very local intrinsic collaterals and projection to TE (2) TEO neurons projecting more widely in the intrinsic network, but not to TE. These parallel systems might be specialized for, respectively, fast vs. highly processed signals.

我们使用两步法结合活体解剖成像，研究了猕猴前部(TE)和后部下颞叶皮质(TEO)的物体识别回路。在步骤1中，将红色荧光示踪剂注射到TE内，以显示TEO内前馈神经元的靶前斑块。在步骤2中，将这些细胞显示在活体皮质表面，并注射绿色荧光示踪剂。组织学处理显示，注射部位&GT；500μm的斑块由混合的绿色Teo固有投射神经元和红色Teo-to-TE神经元组成，仅有少量双标神经元。相比之下，TEO注射部位附近的斑块含有许多双标记神经元。提出了两个平行的空间混合回路：(1)TEO神经元具有非常局部的内源性侧支，并投射到TE；(2)TEO神经元在内源性网络中投射得更广，但不投射到TE。这些并行系统可能分别专用于快速信号和高处理信号。

项目成果

Reciprocal Connectivity of Identified Color-Processing Modules in the Monkey Inferior Temporal Cortex

• DOI: 10.1093/cercor/bhq211
• 发表时间: 2011-06-01
• 期刊: CEREBRAL CORTEX
• 影响因子: 3.7
• 作者: Banno, Taku;Ichinohe, Noritaka;Komatsu, Hidehiko
• 通讯作者: Komatsu, Hidehiko

Neurotrophin-3 is involved in the formation of apical dendritic bundles in cortical layer 2 of the rat.

• DOI: 10.1093/cercor/bhp093
• 发表时间: 2010-01
• 期刊: Cerebral cortex (New York, N.Y. : 1991)
• 作者: Miyashita T;Wintzer M;Kurotani T;Konishi T;Ichinohe N;Rockland KS
• 通讯作者: Rockland KS

Pathway-specific utilization of synaptic zinc in the macaque ventral visual cortical areas.

• DOI: 10.1093/cercor/bhq028
• 发表时间: 2010-12
• 期刊: Cerebral cortex (New York, N.Y. : 1991)
• 作者: Ichinohe N;Matsushita A;Ohta K;Rockland KS
• 通讯作者: Rockland KS

ブレインサイエンスレビュー2012

脑科学评论 2012

• 发表时间: 2012
• 作者: Inoue;T.;Takano;T.;Umesono;Y.;Agata;K.;井上武;井上 武;井上 武;井上 武;井上 武;伊藤正男・川井述史編(井上武)
• 通讯作者: 伊藤正男・川井述史編(井上武)

生体内線維連絡可視化法と線維連絡に基づいた脳機能解明への試み

基于体内纤维通信可视化方法和纤维通信阐明大脑功能的尝试

• 发表时间: 2010
• 作者: Hara;H.;Aoki;S.;Takemura;A.;一戸紀孝
• 通讯作者: 一戸紀孝