Inhalation of antitubercular agents for efficient treatment of tuberculosis

我们发现，气管内给药装置有利于将制成干粉微粒的抗结核药物局部输送到实验动物的肺内。由聚乙醇酸-乳酸(PLGA)和抗结核药物利福平组成的干粉，通过其被巨噬细胞有效摄取的方式，在肺泡区广泛分布，对细胞内的牛分枝杆菌BCG显示出较高的抗结核活性。我们成功地研制出了基于文丘里效应的大鼠气管内给药装置，将干粉均匀地输送到大鼠的肺内，其体积只有几毫升。

We found that intratracheal administration apparatus was beneficial to local delivery of antituberculosis agent formulated into dry powder microparticles to the lung of laboratory animals. The dry powders consisted of poly(glycolic-co-lactic) acid (PLGA) and the antitubercular agent rifampicin showed high antituberculosis activity in intracelluarly residing Mycobacterium bovisBCG by their efficient taken up by the macrophages in such a way that the powders were distributed widely in the alveoli region. We succeeded in developing the intratracheal administration apparatus based on Venturi effect and homogeneous delivery of the dry powders into the lung of rats, the volume of which was in a range of only several milliliters.