Inhalation of antitubercular agents for efficient treatment of tuberculosis

我们发现气管内给药器有利于将配制成干粉微粒的抗结核药物局部输送到实验动物的肺部。由聚乙二醇-共乳酸（PLGA）和抗结核药物利福平组成的干粉通过被巨噬细胞有效吸收，在肺泡区广泛分布，对细胞内驻留的bovisBCG表现出较高的抗结核活性。我们成功地研制了基于文丘里效应的气管内给药装置，并将干粉均匀地输送到大鼠肺中，其体积仅在几毫升范围内。

We found that intratracheal administration apparatus was beneficial to local delivery of antituberculosis agent formulated into dry powder microparticles to the lung of laboratory animals. The dry powders consisted of poly(glycolic-co-lactic) acid (PLGA) and the antitubercular agent rifampicin showed high antituberculosis activity in intracelluarly residing Mycobacterium bovisBCG by their efficient taken up by the macrophages in such a way that the powders were distributed widely in the alveoli region. We succeeded in developing the intratracheal administration apparatus based on Venturi effect and homogeneous delivery of the dry powders into the lung of rats, the volume of which was in a range of only several milliliters.