Inhalation of antitubercular agents for efficient treatment of tuberculosis

我们发现，肺内给药装置有利于将抗结核药物配制成干粉微粒局部递送到实验动物的肺中。由聚（乙醇酸-共-乳酸）（PLGA）和抗结核药利福平组成的干粉在细胞内存在的牛分枝杆菌BCG中显示出高的抗结核活性，其有效地被巨噬细胞以这样的方式摄取，粉末广泛分布在肺泡区域。我们成功地开发了基于文丘里效应和将干粉均匀递送到大鼠肺中的肺内给药装置，其体积在仅几毫升的范围内。

We found that intratracheal administration apparatus was beneficial to local delivery of antituberculosis agent formulated into dry powder microparticles to the lung of laboratory animals. The dry powders consisted of poly(glycolic-co-lactic) acid (PLGA) and the antitubercular agent rifampicin showed high antituberculosis activity in intracelluarly residing Mycobacterium bovisBCG by their efficient taken up by the macrophages in such a way that the powders were distributed widely in the alveoli region. We succeeded in developing the intratracheal administration apparatus based on Venturi effect and homogeneous delivery of the dry powders into the lung of rats, the volume of which was in a range of only several milliliters.