Molecular mechanisms underlying the effects of molecular hydrogen on health promotion and disease control

氢分子对健康促进和疾病控制影响的分子机制

• 批准号: 22300244
• 负责人: ITO Masafumi
• 金额: $ 11.73万
• 依托单位: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2011-2012)Institute of Applied Biochemistry (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300244/
• 关键词: 水素; シグナル伝達; 酸化ストレス

The effects of molecular hydrogen have been reported in various diseases. A selective scavenging of hydroxyl radicals was proposed as an underlying mechanism of the hydrogen effects and indeed a reduction of the oxidative damage by hydrogen has been observed. In cell culture models of inflammation and fatty liver as well as type I allergy, we have demonstrated that hydrogen does not affect the oxidative signal that is physiologically important but inhibits the intracellular signal transduction, thereby exerting beneficial effects. Based on these findings, we have established the modulation of signal transduction as a novel mechanism of the effects of hydrogen.

分子氢在各种疾病中的作用已有报道。对羟基自由基的选择性清除被认为是氢效应的一个潜在机制，而且确实观察到了氢对氧化损伤的减少。在炎症、脂肪肝以及I型变态反应的细胞培养模型中，我们已经证明了氢不影响生理上重要的氧化信号，但抑制了细胞内的信号转导，从而发挥了有益的作用。基于这些发现，我们建立了信号转导的调制作为氢效应的一种新机制。

项目成果

Hesperetin Upregulates ABCA1 Expression and Promotes Cholesterol Efflux from THP-1 Macrophages

• DOI: 10.1021/np200696r
• 发表时间: 2012-04-01
• 期刊: JOURNAL OF NATURAL PRODUCTS
• 影响因子: 5.1
• 作者: Iio, Akio;Ohguchi, Kenji;Ito, Masafumi
• 通讯作者: Ito, Masafumi

Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases.

• DOI: 10.1155/2012/353152
• 发表时间: 2012
• 期刊: Oxidative medicine and cellular longevity
• 作者: Ohno K;Ito M;Ichihara M;Ito M
• 通讯作者: Ito M

分子状水素によるI型アレルギー抑制機構の解明

阐明分子氢抑制 I 型过敏的机制

• 发表时间: 2010
• 作者: 伊藤智広;藤田泰典;伊藤美佳子;増田章男;市原正智;小島俊男;野澤義則;大野欽司;伊藤雅史
• 通讯作者: 伊藤雅史

Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats.

• DOI: 10.1186/2045-9912-2-15
• 发表时间: 2012-05-20
• 期刊: Medical gas research
• 影响因子: 2.9
• 作者: Ito M;Hirayama M;Yamai K;Goto S;Ito M;Ichihara M;Ohno K
• 通讯作者: Ohno K

水素によるシグナル伝達の制御

氢对信号转导的调节

• 发表时间: 2013
• 作者: Terazawa R;Garud DR;Hamada N;Fujita Y;Itoh T;Nozawa Y;Nakane K;Deguchi T;Koketsu M;Ito M;伊藤雅史
• 通讯作者: 伊藤雅史