Search for Natural Products which Enhance the Function of TumorSuppressor Protein and Study of the Mechanisms of Effects

增强肿瘤抑制因子p53功能的化合物是有希望的抗癌先导物。我们从天然来源中寻找化合物。目前，我们已经报道了E1、E2和E3的抑制剂，它们对靶蛋白的多聚泛素化起作用。在这个项目中，我们寻找多聚泛素化p53的募集抑制剂用于癌症治疗。

Compounds, which enhance the function of tumor suppressor p53,are promising anti-cancer leads. We search for the compounds from natural sources. Sofar we reported the inhibitors of E1, E2, and E3, which function for the polyubiquitinationof target proteins. In this project, we search for inhibitors of the recruitment of thepolyubiquitinated p53 for the cancer treatment.