Structure of Substrate-bound Nitric Oxide Reductases

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The structures of quinol and cytochrome c-dependent nitric oxide reductases, which catalyze the reduction of NO to produce N2O, has been characterized. The structure-based mutagenesis and molecular dynamics simulation studies of qNOR suggest that a water channel from the cytoplasm can serve as a proton transfer pathway for the catalytic reaction. Further structural comparison of qNOR with cNOR and aerobic and microaerobic respiratory oxidases elucidates their evolutionary relationship and possible functional conversions.