Chemical Biology on Cancer and Neurodegenerative disease

1)我们发现SO286通过溶酶体降解途径抑制MPP+诱导的蛋白聚集。我们试图确定SO286抑制MPP+诱导的斑点形成和调控机制的靶蛋白。2)我们报道了5-脂氧合酶（5-LOX）在细胞迁移过程中被激活并产生白三烯C4(LTC4)， 5-LOX抑制剂抑制细胞迁移。接下来，我们确定了半胱氨酸白垩烯受体1 （CysLT1）拮抗剂也阻断c

1）We showed that SO286 inhibited protein aggregation induced by MPP+ through lysosomal degradation pathway. We attempted to identify the target protein of SO286 responsible for the mechanism of SO286 inhibited the MPP+-induced dot formation and regulation2）We report that 5-lipoxygenase (5-LOX) is activated and produces leukotriene C4(LTC4) in the process of cell migration, and 5-LOX inhibitors suppressed cell migration. Next, we identified cysteinyl leukotoriene receptor 1 (CysLT1) antagonist also block c