Chemical Biology on Cancer and Neurodegenerative disease

癌症和神经退行性疾病的化学生物学

• 批准号: 22310140
• 负责人: IMOTO Masaya
• 金额: $ 11.98万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22310140/
• 关键词: CysLT1アンタゴニスト; がん転移; オートファジー; パーキンソン疾患; パーキンソン病; 細胞遊走; CysLT1; ケミカルバイオロジー; パーキンソン症; がん; α-synuclein; 5-リポキシゲナーゼ

1）We showed that SO286 inhibited protein aggregation induced by MPP+ through lysosomal degradation pathway. We attempted to identify the target protein of SO286 responsible for the mechanism of SO286 inhibited the MPP+-induced dot formation and regulation2）We report that 5-lipoxygenase (5-LOX) is activated and produces leukotriene C4(LTC4) in the process of cell migration, and 5-LOX inhibitors suppressed cell migration. Next, we identified cysteinyl leukotoriene receptor 1 (CysLT1) antagonist also block c

1）SO286通过溶酶体降解途径抑制MPP+诱导的蛋白聚集。2）在细胞迁移过程中，5-脂氧合酶（5-LOX）被激活并产生白三烯C4（LTC 4），5-LOX抑制剂抑制细胞迁移。接下来，我们确定了半胱氨酰白三烯受体1（CysLT 1）拮抗剂也可以阻断C-反应。

项目成果

Antitumor effects of novel highly hydrophilic and non-ATP-competitive MEK1/2 inhibitor

新型高亲水性和非 ATP 竞争性 MEK1/2 抑制剂的抗肿瘤作用

• 发表时间: 2012
• 期刊: SMK-17. Anticancer Drugs.
• 作者: Kiga M;Tanzawa F;Iwasaki S;Inaba F;Fujiwara K;IwadareH;Echigo T;Nakamura Y;Shibata T;Suzuki K;Yasumatsu;I Nakayama A;Sasazawa Y;Tashiro E;Imoto M;S. Kurakata S
• 通讯作者: S. Kurakata S

新たなアンドロゲンアンタゴニストの検索のためのアプローチ

寻找新雄激素拮抗剂的方法

• 作者: 藤巻貴宏;田代悦;井本正哉
• 通讯作者: 井本正哉

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

• DOI: 10.4161/auto.7.2.14074
• 发表时间: 2011-02-01
• 期刊: AUTOPHAGY
• 影响因子: 13.3
• 作者: Saiki, Shinji;Sasazawa, Yukiko;Hattori, Nobutaka
• 通讯作者: Hattori, Nobutaka

Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications.

• DOI: 10.1186/1472-6769-12-2
• 发表时间: 2012-04-05
• 期刊: BMC chemical biology
• 作者: Kobayashi H;Harada H;Nakamura M;Futamura Y;Ito A;Yoshida M;Iemura SI;Shin-Ya K;Doi T;Takahashi T;Natsume T;Imoto M;Sakakibara Y
• 通讯作者: Sakakibara Y

Inostamycin enhanced TRAIL-induced apoptosis through DR5 upregulation on the cell surface

肌霉素通过细胞表面 DR5 上调增强 TRAIL 诱导的细胞凋亡

• DOI: 10.1038/ja.2012.21
• 发表时间: 2012
• 期刊: The Journal of Antibiotics
• 作者: Kohta Yamamoto;Masafumi Makino;R. Watanapokasin;E. Tashiro;M. Imoto
• 通讯作者: M. Imoto