New Development of Catalytic Fluoroalkylation

有机氟化合物由于其独特的物理和化学性质，在各种工业领域受到广泛关注。其中，三氟甲基化芳香族化合物（Ar-CF3）是各工业领域中备受关注的物质。由于对氟芳烃的需求不断增加，从成本、简单性、效率、多功能性和环境友好的角度出发，需要新的芳烃三氟甲基化方法，包括催化过程。我们已经成功地开发了一种芳香三氟甲基化的催化程序，使用三氟乙醛半胺衍生物作为容易获得的交叉偶联伙伴。此外，我们还开发了通过2-芳基-2,2-二氟乙酸酯高效合成二氟甲基化芳烃（Ar-CF2H）和单氟甲基化芳烃（Ar-CFH2）的反应序列。

Organofluorine compounds are the substances of considerable interest in various industrial fields due to their unique physical and chemical properties. Among them, trifluoromethylated aromatic compounds (Ar-CF3) are the substances of considerable interest in various industrial fields. Owing to the increasing demands for fluoroaromatics, new methodologies for aromatic trifluoromethylation have been required from the viewpoints of cost, simplicity, efficiency, versatility, and environmental benignity including a catalytic process. We have succeeded in the development of a catalytic procedure for aromatic trifluoromethylation by the use of trifluoroacetaldehyde hemiaminal derivatives as readily available cross-coupling partners. Furthermore, we have developed reaction sequences leading to efficient synthesis of difluoromethylated aromatics (Ar-CF2H) and monofluoromethylated aromatics (Ar-CFH2) via 2-aryl-2,2-difluoroacetates.