Creation of Functional Artificial Peptide Nanocapsules based onInternal Skeleton of Viral Capsids

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Recently, application of plant viruses to nanotechnology have attracted much attention due to their fascinating nanostructures with discrete nano-space. However, it remains difficult to rationally design artificial viral capsid. In this project, we found that a synthesized viral β-annulus peptide (24 residues) showed spontaneous self-assembly into hollow nanocapsules (synthetic viral capsid) with the size of 30-50 nm in water. Moreover, we have succeeded in synthesizing magnetite and encapsulating M13 phage DNA into the artificial capsids.