Development of Accistance System for High Accuracy Breast Cancer Radio Frequency Ablation

高精度乳腺癌射频消融辅助系统的研制

• 批准号: 22360108
• 负责人: YOSHIMURA Masataka
• 金额: $ 12.06万
• 依托单位: Waseda University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22360108/
• 关键词: 乳がん; ラジオ波焼灼療法; 治療支援システム; 生体医工学; シミュレーション; モデルベース制御; 熱物性; 温度分布シミュレーション

Recently the radio frequency ablation (RFA) treatment is focused on as minimally invasive treatment for breast cancer. In order to improve treatment effect of RFA, we developed the support system of RFA treatment for breast cancer ablation high accurately. Our system mainly consists of high accuracy temperature distribution simulator and optimal process for puncture. As the results of some in vivo experiments, the temperature distribution simulator enable to be high repeatability that the temperature difference between experimental results and analysis results is within 4.0 deg C. And, in obtaining the process of optimal puncture for breast cancer, we developed the optimal puncture condition. This condition was derived from in vitro experiments by using simulant cancer which was implanted in hog breast.

最近，射频消融（RFA）治疗作为乳腺癌的微创治疗受到关注。为了提高RFA治疗效果，我们开发了高精度乳腺癌消融RFA治疗支持系统。我们的系统主要由高精度温度分布模拟器和穿刺优化流程组成。根据一些体内实验的结果，温度分布模拟器具有很高的重复性，实验结果与分析结果之间的温度差异在4.0℃以内。并且，在获得乳腺癌最佳穿刺的过程中，我们开发了最佳穿刺条件。该条件是通过使用植入猪胸肉的模拟癌症进行的体外实验得出的。

项目成果

A method for deriving the coagulation boundary of liver tissue using a relational model of viscoelasticity and temperature in radio frequency ablation

• DOI: 10.1109/embc.2012.6345902
• 发表时间: 2012-11
• 期刊: 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
• 作者: X. Lu;M. Tsukune;Hiroki Watanabe;N. Yamazaki;Y. Isobe;Yo Kobayashi;T. Miyashita;M. Fujie

RFA において非対称形状の焼灼領域形成を可能にする電極針の機構の検討

研究在 RFA 中形成不对称形状消融区域的电极针机制

• 发表时间: 2012
• 作者: Kitamura N;Yasuda K : 他5名;磯部 洋佑,山崎 望,渡辺 広樹,小林 洋,宮下 朋之,大平 猛,橋爪 誠,藤江 正克
• 通讯作者: 磯部 洋佑,山崎 望,渡辺 広樹,小林 洋,宮下 朋之,大平 猛,橋爪 誠,藤江 正克

Modeling the internal pressure dependence of thermal conductivity and in vitro temperature measurement for lung RFA

• DOI: 10.1109/iembs.2011.6091424
• 发表时间: 2011-12
• 期刊: 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society
• 作者: N. Yamazaki;Hiroki Watanabe;M. Seki;T. Hoshi;Yo Kobayashi;T. Miyashita;M. Fujie

A Method for Distinguishing Coagulation Boundary for Liver RF Ablation

肝脏射频消融凝固边界的区分方法

• 发表时间: 2012
• 作者: Satoshi Yamaguchi;Yoshinori Yoshida;Kazumichi Wakabayashi;Tadashi Nagashima;Fumio Takeshige;Yusuke Kawamoto;Hiroshi Noborio;Taiji Sohmura;高木寛之,香川亮太,細川聖,野川雅道,田中志信,山越憲一,齊藤浩一;呂筱薇,築根まり子,山崎望,渡辺広樹,小林洋,宮下朋之,藤江正克
• 通讯作者: 呂筱薇,築根まり子,山崎望,渡辺広樹,小林洋,宮下朋之,藤江正克

Temperature Dependence of Thermal Conductivity of Liver Based on Various Experiments and a NumericalSimulation for RF Ablation

基于各种实验和射频消融数值模拟的肝脏热导率的温度依赖性

• 发表时间: 2010
• 作者: Hiroki Watanabe;Nozomu Yamazaki;Yo Kobayashi;Tomoyuki Miyashita;Makoto Hashizume;Masakatsu G. Fujie
• 通讯作者: Masakatsu G. Fujie