Study on the mode of action of Draper, a multi-ligand engulfmentreceptor of Drosophila

研究了果蝇吞噬细胞的吞噬受体Draper的作用方式。当吞噬细胞识别凋亡细胞时，Draper经历了NPxY基序的酪氨酸磷酸化。Draper需要这种酪氨酸残基来传递诱导吞噬的信号。内质网蛋白CaBP1和膜磷脂磷脂酰丝氨酸是Draper的配体。此外，整合素αPS3-βν被鉴定为另一种不依赖Draper的吞噬受体。

The modes of action of Draper, an engulfment receptor responsible for the phagocytosis of apoptotic cells in Drosophila, were investigated. Draper underwent tyrosine phosphorylation at the motif NPxY when phagocytes recognized apoptotic cells. This tyrosine residue was required for Draper to transmit signals for the induction of phagocytosis. The endoplasmic reticulum protein CaBP1 and the membrane phospholipid phosphatidylserine were found to serve as ligands for Draper. In addition, integrin αPS3-βν was identified as another engulfment receptor that functions independent of Draper.