Research of tumor development due to failure in cell competition

我们产生了一个果蝇品系，它缺乏负责吞噬细胞去除凋亡细胞的受体。这些果蝇的幼虫期延长，表明凋亡细胞清除在生长中的重要性。为了确定由于吞噬缺陷而残留在动物体内的“失败者细胞”的特征，将用于人工细胞竞争的镶嵌突变引入到吞噬缺陷的苍蝇系中。然而，我们未能在分配的研究期内完成对这些苍蝇的检查。

We generated a Drosophila line that lacks receptors responsible for the phagocytic removal of apoptotic cells. These flies had prolonged larval stage, indicating the importance of apoptotic cell clearance in growth. To determine the characteristic of' loser cells', which remain in animals due to a defect in phagocytosis, a mosaic mutation for artificial cell competition was introduced into a phagocytosis-deficient fly line. However, we could not complete the examination of these flies within the allocated research period.