A study on polymorphisms associated with obesity and lipid profile in the Oceanic populations

与海洋人群肥胖和血脂相关的多态性研究

• 批准号: 22370084
• 负责人: OHASHI Jun
• 金额: $ 12.73万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22370084/
• 关键词: オセアニア; 肥満; 多型; 倹約遺伝子; BMI; 脂質代謝; オーストロネシア語族; 遺伝子; 倹約遺伝子仮説; 糖代謝

A SNP located upstream of ADRB2, rs34623097, showed the strongest association with obesity in a logistic regression analysis adjusted for age, sex, and population (P = 5.6 x 10-4, odds ratio [OR] = 2.5, 95% confidence interval [CI] = 1.5-4.2).To study the origin of Polynesians and the gene flow from Polynesian ancestors to indigenous Melanesians, a 48-bp variable number of tandem repeat (VNTR) in exon 3 of the dopamine D4 receptor (DRD4) gene was investigated for six Austronesian (AN)-speaking populations. Our results provide evidence of gene flow from Polynesian ancestors to indigenous Melanesians while Polynesian ancestors passed through Melanesia.A candidate gene association analysis on 11 metabolic traits of 5,810 East Asians revealed that rs1057001, a T/A transversion polymorphism in 3'untranslated region (UTR) of TRIB2, was strongly associated with visceral fat area (VFA) and waist circumference adjusted for body mass index (P = 2.7 × 10(-6) and P = 9.0 × 10(-6), respectively).

经年龄、性别和人群校正后的logistic回归分析显示，位于ADRB2上游的SNP rs34623097与肥胖的相关性最强（P = 5.6 × 10-4，优势比[OR] = 2.5, 95%可信区间[CI] = 1.5-4.2）。为了研究波利尼西亚人的起源以及波利尼西亚人祖先向本土美拉尼西亚人的基因流动，研究了6个南岛人（AN）种群多巴胺D4受体（DRD4）基因外显子3的48 bp可变数串联重复序列（VNTR）。我们的研究结果提供了波利尼西亚祖先向土著美拉尼西亚人的基因流动的证据，而波利尼西亚祖先则通过美拉尼西亚。通过对5810名东亚人11个代谢性状的候选基因关联分析，发现TRIB2 3'非翻译区（UTR） T/A翻转多态性rs1057001与内脏脂肪面积（VFA）和体重指数校正后的腰围密切相关（P = 2.7 × 10（-6）和P = 9.0 × 10(-6)）。

项目成果

Testing the thrifty gene hypothesis: the Gly482Ser variant in PPARGC1A is associated with BMI in Tongans.

• DOI: 10.1186/1471-2350-12-10
• 发表时间: 2011-01-18
• 期刊: BMC medical genetics
• 作者: Myles S;Lea RA;Ohashi J;Chambers GK;Weiss JG;Hardouin E;Engelken J;Macartney-Coxson DP;Eccles DA;Naka I;Kimura R;Inaoka T;Matsumura Y;Stoneking M
• 通讯作者: Stoneking M

β2アドレナリン受容体遺伝子(ADRB2) 上流領域SNPの進化遺伝学的解析

β2肾上腺素受体基因（ADRB2）上游区域SNP的进化遗传分析

• 作者: Fukuba Y;Shinhara Y;Houman T;Endo MY;Yamada M;Miura A;Hayashi N;Sato H;Koga S;Yoshida T;Higuchi S;覚張隆史,山崎京美,米田穣;中 伊津美 ほか
• 通讯作者: 中 伊津美 ほか

The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population

• DOI: 10.1038/jhg.2010.75
• 发表时间: 2010-09-01
• 期刊: JOURNAL OF HUMAN GENETICS
• 影响因子: 3.5
• 作者: Onuma, Hiroshi;Tabara, Yasuharu;Osawa, Haruhiko
• 通讯作者: Osawa, Haruhiko

Association of CTXN3-SLC12A2 polymorphisms and schizophrenia in a Thai population.

• DOI: 10.1186/1744-9081-8-27
• 发表时间: 2012-05-29
• 期刊: Behavioral and brain functions : BBF
• 作者: Panichareon B;Nakayama K;Iwamoto S;Thurakitwannakarn W;Sukhumsirichart W
• 通讯作者: Sukhumsirichart W

The VNTR polymorphism of the dopamine D4 receptor (DRD4) genein Oceanic populations

海洋种群多巴胺D4受体(DRD4)基因的VNTR多态性

• 发表时间: 2010
• 作者: Naka I;et al.
• 通讯作者: et al.