Acquisition of the meiotic and mitotic competence during oocyte growth

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Mammalian oocytes acquire the competence for meiotic maturation ad subsequent development during their growth in the ovaries. However, a part of fully grown oocytes do not have this competence. In the present study, to determine the factor(s) involved in this competence, I conducted the transcriptome analysis for the oocytes with and without the competence. Several candidates for the factor were obtained from this analysis. By inhibiting the expression of these candidates in the growing oocytes, I determined the target factors.