Syntheses of Bioactive Compounds using Functional Carbanions

羰基酸盐和宝石-碘离子等功能碳离子及其新反应的发展，以及通过这些新反应合成的生物活性化合物。利用野糖引发的串联反应，实现了中药中药Stemona japonica成分之一的stemonamine的全合成。双溴酰胺双锂化反应生成了新的活性物质宝石-钻石离子。利用迭安离子，建立了串联芳取代-电环反应，得到了苯并异喹啉。炔醇酯烯烃的-杂原子效应表明-烷氧基酯烯烃反应活性高。使用流动微反应器，可以在环境温度下制备醇化物

Functional carbanions, such as ynolates and gem-dianions, and their new reactions were developed, and bioactive compounds were synthesizedvia these new reactions. Total synthesis stemonamine, one of contents of traditional Chinese medicine, Stemona japonica, was achieved by using the tandemreaction initiated by ynoaltes. New reactive species, gem-dianions, were generated by double lithiation of dibromoamides. Using the dianions, tandem aromatic substitution-electrocyclic reaction affording benzoisoqunoline was developed. An -heteroatom effect of olefination with ynoaltes revealed the high reactivity of -alkoxy esters towards olefination. Using a flow microreactor, ynolates could beprepared at ambient temperature