Study of new broad spectrum of anti-parasitic agent and basis of molecular base of it

N-89治疗疟疾和血吸虫病的作用机制：（1）应用综合蛋白质组学技术，N-89共改变了曼氏血吸虫11种蛋白质。其中，用N-89处理24小时后，副肌球蛋白减少至对照的30%。疟原虫和S.在本研究中，曼氏菌与N-89在蛋白质组学上不是相似的靶分子，并且有必要进一步验证两种病原体中的差异。(2)体长S.体内实验表明，N-89能缩短曼氏菌的生长时间，并能减少疟原虫色素的生成。(3)罗丹明-N-89加合物可明显地掺入寄生虫体内。

The mechanism of action of N-89 for malaria and schistosomiasis;(1) Total 11 of proteins were changed by N-89 in Schistosoma mansoniusing comprehensive proteomics. Among them, paramyosin was reduced to 30% of control after 24hr treatment with N-89. Malaria parasite and S. mansoniwere not similar target molecules in proteomics with N-89 in the study and it will be necessary to validate further the differences in both 2 pathogens.(2) Body length of S. mansoni was shorted by N-89 administration and production of hemozoin also decreased in vivo experiment.(3) Rhodamine-N-89 adducts will may act incorporated into the parasite body clearly.