Functional analysis of IFITM3 in neurodevelopmental impairments

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The role of interferon-induced transmembrane protein 3 (IFITM3) in the CNS is largely unknown, despite the fact that its expression is increased in the brains of patients with neurologic and neuropsychiatric diseases. In the present study we show the role of IFITM3 in long-lasting neuronal impairments in mice following polyI:C-induced immune challenge during the early stages of development. Our findings suggest that the induction of IFITM3 expression in astrocytes by the activation of the innate immune system during the early stages of development has non-cell autonomous effects that affect subsequent neurodevelopment, leading to neuropathological impairments and brain dysfunction, by impairing endocytosis in astrocytes.