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ANALYSES OF DYNAMIC CHANGES AND THE FUNCTION OF TISSUE PLASMINOGEN ACTIVATOR IN ANIMAL MODELS OF DOPAMINE-RELATED MENTAL DISORDERS

ANALYSES OF DYNAMIC CHANGES AND THE FUNCTION OF TISSUE PLASMINOGEN ACTIVATOR IN ANIMAL MODELS OF DOPAMINE-RELATED MENTAL DISORDERS
多巴胺相关精神障碍动物模型中组织纤溶酶原激活剂的动态变化和功能分析
批准号:
19390062
负责人:
YAMADA Kiyofumi
金额:
$10.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
In the present study we investigated whether tissue plasminogen activator (tPA)-plasmin system was involved in the pathophysiology/pathogenesis of dopamine-related neuropsychiatric disorders, by using animal models for the diseases. Our findings suggest that tPA-plasmin may play a role in the development of methamphetamine dependence as well as methamphetamine-induced psychosis. Furthermore, it is indicated that the activation of dopamine D1 receptors leads to an increase in extracellular tPA activity and the dopamine D1 receptor-tPA signaling may play a role in memory formation.
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DOI: 10.1111/j.1471-4159.2007.04946.x
发表时间: 2007-12
期刊: Journal of Neurochemistry
影响因子: 4.7
作者: [Mina Ito;T. Nagai;H. Mizoguchi;Kosuke Sato;M. Hayase;N. Otsuka;Ayumi Fukakusa;Nozomi Kumagai;Hyoung‐Chun Kim;T. Nabeshima;K. Takuma;Kiyofumi Yamada]
通讯作者: Mina Ito;T. Nagai;H. Mizoguchi;Kosuke Sato;M. Hayase;N. Otsuka;Ayumi Fukakusa;Nozomi Kumagai;Hyoung‐Chun Kim;T. Nabeshima;K. Takuma;Kiyofumi Yamada
Ovariectomy increases neuronal amyloid β binding alchohol dehydrogenease level in the mouse hippocampus.
卵巢切除术增加了小鼠海马神经元淀粉样蛋白结合乙醇脱氢酶的水平。
DOI: --
发表时间: 2008
期刊: Neurochem. Int. 52
影响因子: --
作者: [Fukuzaki, et al.]
通讯作者: et al.
Synergistic influence of neonatal immune activation and mutant DISCI on phenotypic changes in adulthood
新生儿免疫激活和突变体 DISCI 对成年表型变化的协同影响
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Ibi D, et al.]
通讯作者: et al.
The role of tissue plasminogen activator in methamphetamine-induced reward, behavioral sensitization and cognitive deficit in mice.
组织纤溶酶原激活剂在甲基苯丙胺诱导的小鼠奖赏、行为敏化和认知缺陷中的作用。
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [Yamada K, et. al.]
通讯作者: et. al.
28
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      23659135
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    • 项目类别:
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    • 负责人:
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