ANALYSES OF DYNAMIC CHANGES AND THE FUNCTION OF TISSUE PLASMINOGEN ACTIVATOR IN ANIMAL MODELS OF DOPAMINE-RELATED MENTAL DISORDERS
ANALYSES OF DYNAMIC CHANGES AND THE FUNCTION OF TISSUE PLASMINOGEN ACTIVATOR IN ANIMAL MODELS OF DOPAMINE-RELATED MENTAL DISORDERS
批准号:
19390062
负责人:
YAMADA Kiyofumi
金额:
$10.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
点击翻译按钮获取中文摘要
英文摘要
In the present study we investigated whether tissue plasminogen activator (tPA)-plasmin system was involved in the pathophysiology/pathogenesis of dopamine-related neuropsychiatric disorders, by using animal models for the diseases. Our findings suggest that tPA-plasmin may play a role in the development of methamphetamine dependence as well as methamphetamine-induced psychosis. Furthermore, it is indicated that the activation of dopamine D1 receptors leads to an increase in extracellular tPA activity and the dopamine D1 receptor-tPA signaling may play a role in memory formation.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
DOI:
10.1111/j.1471-4159.2007.04946.x
发表时间:
2007-12
期刊:
Journal of Neurochemistry
影响因子:
4.7
作者:
[Mina Ito;T. Nagai;H. Mizoguchi;Kosuke Sato;M. Hayase;N. Otsuka;Ayumi Fukakusa;Nozomi Kumagai;Hyoung‐Chun Kim;T. Nabeshima;K. Takuma;Kiyofumi Yamada]
通讯作者:
Mina Ito;T. Nagai;H. Mizoguchi;Kosuke Sato;M. Hayase;N. Otsuka;Ayumi Fukakusa;Nozomi Kumagai;Hyoung‐Chun Kim;T. Nabeshima;K. Takuma;Kiyofumi Yamada
Ovariectomy increases neuronal amyloid β binding alchohol dehydrogenease level in the mouse hippocampus.
卵巢切除术增加了小鼠海马神经元淀粉样蛋白结合乙醇脱氢酶的水平。
DOI:
--
发表时间:
2008
期刊:
Neurochem. Int. 52
影响因子:
--
作者:
[Fukuzaki, et al.]
通讯作者:
et al.
Synergistic influence of neonatal immune activation and mutant DISCI on phenotypic changes in adulthood
新生儿免疫激活和突变体 DISCI 对成年表型变化的协同影响
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Ibi D, et al.]
通讯作者:
et al.
The role of tissue plasminogen activator in methamphetamine-induced reward, behavioral sensitization and cognitive deficit in mice.
组织纤溶酶原激活剂在甲基苯丙胺诱导的小鼠奖赏、行为敏化和认知缺陷中的作用。
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Yamada K, et. al.]
通讯作者:
et. al.
Ginkgo blioba extract EGb761 attenuates hippocampal neuronal loss and cognitivedysfunction resultine from chronic restraint stress in ovariectomized rats.
银杏叶提取物 EGb761 可减轻卵巢切除大鼠慢性束缚应激导致的海马神经元损失和认知功能障碍。
DOI:
--
发表时间:
2007
期刊:
Neuroscience 149
影响因子:
--
作者:
[Takuma K, et. al.]
通讯作者:
et. al.
共 28 条
Effect of drugs of abuse on reward-based decision-making in rodents
-
批准号:23659135
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2011
-
负责人:YAMADA Kiyofumi
-
依托单位:
Functional analysis of IFITM3 in neurodevelopmental impairments
-
批准号:22390046
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.06万
-
财政年份:2010
-
负责人:YAMADA Kiyofumi
-
依托单位:
The origin of brain tumor
-
批准号:20791004
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2008
-
负责人:YAMADA Kiyofumi
-
依托单位:
Role of brain-derived neurotrophic factor (BDNF) in learning and memory
-
批准号:12670085
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.11万
-
财政年份:2000
-
负责人:YAMADA Kiyofumi
-
依托单位:
海外基金