Development of a novel tumor immunotherapy that targets the soluble poliovirus receptor

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An activated immune receptor, DNAM-1, on T cells and NK cells binds to membrane-type poliovirus receptor (PVR) expressed on tumor cells, resulting in the immune surveillance against carcinogenesis. On the other hand, we found that the soluble PVR produced from tumor cells was involved in the escape from immune surveillance by DNAM-1. These results suggest that the soluble PVR can potentially be a target for novel cancer therapy that inhibit an immune escape, enhancing tumor immune surveillance by DNAM-1.