A role of LFA-1 in the development of autoreactive Th17 cells
A role of LFA-1 in the development of autoreactive Th17 cells
批准号:
19390270
负责人:
SHIBUYA Kazuko
金额:
$11.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
In the present study, we have evaluated a role of LFA-1 in the development of EAE using LFA-1-deficient mice. We demonstrate that LFA-1plays an important role in both autoantigen-specific T cell immigration to the draining lymph nodes (dLN) and development of Th17 cells, leading to the development of EAE.
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Increased anti-PC natural IgM production and resistance against Streptococcus pneumoniae infection in mice deficient in Fca/mR, an Fc receptor for IgA and IeM
缺乏 Fca/mR(IgA 和 IeM 的 Fc 受体)的小鼠中,抗 PC 天然 IgM 的产生增加,对肺炎链球菌感染的抵抗力增强
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Yano, M., Kuroda, N., Han, H., Horike, M., Nishikawa, Y., Kiyonari, H., Maemura, K., Yanagawa, Y., Obata, K., Takahashi, S., Ikawa, T., Satoh, R., Kawamoto, H., Mouri, Y., and Matsumoto, M., Honda S. et al]
通讯作者:
Honda S. et al
Identification of the Fcα/μR Isoform Specifically Expressed in the Kidney.
肾脏中特异性表达的 Fcα/μR 同工型的鉴定。
DOI:
--
发表时间:
2009
期刊:
Mol. Immunol. 46
影响因子:
--
作者:
[KURITA Naoki, HONDA Shin-ichiro, CHO Yukiko, USUI Kenta, TAKESHITA Kie, TAHARA-HANAOKA Satoko, SHIBUYA Kazuko and SHIBUYA Akira., Kurita N. et al]
通讯作者:
Kurita N. et al
Negative regulation of IgA production by the Fcα/μ recepto, an Fc receptor for IgA and IgM.
Fcα/μ 受体(IgA 和 IgM 的 Fc 受体)对 IgA 产生的负调节。
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[KURITA Naoki, HONDA Shin-ichiro, CHO Yukiko, USUI Kenta, TAKESHITA Kie, TAHARA-HANAOKA Satoko, SHIBUYA Kazuko and SHIBUYA Akira.]
通讯作者:
SHIBUYA Kazuko and SHIBUYA Akira.
IgM suppresses humoral immune responses against T-independent antigens via the Fcα/μR
IgM 通过 Fcα/μR 抑制针对 T 独立抗原的体液免疫反应
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[A Shibuya, C Nakahashi, N Totsuka, S Tahara-Hanaoka., Honda S. et.al.]
通讯作者:
Honda S. et.al.
DOI:
10.1016/j.molimm.2007.04.011
发表时间:
2008-01-01
期刊:
MOLECULAR IMMUNOLOGY
影响因子:
3.6
作者:
[Nakano, Takako, Tahara-Hanaoka, Satoko, Shibuya, Akira]
通讯作者:
Shibuya, Akira
共 43 条
Development of the molecular targeted therapy for the chronic rejection after renal transplantation that control immunological memory
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批准号:26670575
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.33万
-
财政年份:2014
-
负责人:SHIBUYA Kazuko
-
依托单位:
Development of the molecular targeted therapy for allergic dermatitis
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批准号:25293091
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.07万
-
财政年份:2013
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负责人:SHIBUYA Kazuko
-
依托单位:
Development of the novel molecular target therapy for the graft versus host disease (GVHD) using the humanized mice
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批准号:24659176
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
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财政年份:2012
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负责人:SHIBUYA Kazuko
-
依托单位:
Development of a novel tumor immunotherapy that targets the soluble poliovirus receptor
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批准号:22390073
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.9万
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财政年份:2010
-
负责人:SHIBUYA Kazuko
-
依托单位:
Development of a novel molecular therapy for rheumatoid arthritis by regulation of Th1/Th2 differentiation
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批准号:14370167
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.58万
-
财政年份:2002
-
负责人:SHIBUYA Kazuko
-
依托单位:
海外基金