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A role of LFA-1 in the development of autoreactive Th17 cells

A role of LFA-1 in the development of autoreactive Th17 cells
LFA-1 在自身反应性 Th17 细胞发育中的作用
批准号:
19390270
负责人:
SHIBUYA Kazuko
金额:
$11.65万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
In the present study, we have evaluated a role of LFA-1 in the development of EAE using LFA-1-deficient mice. We demonstrate that LFA-1plays an important role in both autoantigen-specific T cell immigration to the draining lymph nodes (dLN) and development of Th17 cells, leading to the development of EAE.
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Increased anti-PC natural IgM production and resistance against Streptococcus pneumoniae infection in mice deficient in Fca/mR, an Fc receptor for IgA and IeM
缺乏 Fca/mR(IgA 和 IeM 的 Fc 受体)的小鼠中,抗 PC 天然 IgM 的产生增加,对肺炎链球菌感染的抵抗力增强
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Yano, M., Kuroda, N., Han, H., Horike, M., Nishikawa, Y., Kiyonari, H., Maemura, K., Yanagawa, Y., Obata, K., Takahashi, S., Ikawa, T., Satoh, R., Kawamoto, H., Mouri, Y., and Matsumoto, M., Honda S. et al]
通讯作者: Honda S. et al
Identification of the Fcα/μR Isoform Specifically Expressed in the Kidney.
肾脏中特异性表达的 Fcα/μR 同工型的鉴定。
DOI: --
发表时间: 2009
期刊: Mol. Immunol. 46
影响因子: --
作者: [KURITA Naoki, HONDA Shin-ichiro, CHO Yukiko, USUI Kenta, TAKESHITA Kie, TAHARA-HANAOKA Satoko, SHIBUYA Kazuko and SHIBUYA Akira., Kurita N. et al]
通讯作者: Kurita N. et al
Negative regulation of IgA production by the Fcα/μ recepto, an Fc receptor for IgA and IgM.
Fcα/μ 受体(IgA 和 IgM 的 Fc 受体)对 IgA 产生的负调节。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [KURITA Naoki, HONDA Shin-ichiro, CHO Yukiko, USUI Kenta, TAKESHITA Kie, TAHARA-HANAOKA Satoko, SHIBUYA Kazuko and SHIBUYA Akira.]
通讯作者: SHIBUYA Kazuko and SHIBUYA Akira.
IgM suppresses humoral immune responses against T-independent antigens via the Fcα/μR
IgM 通过 Fcα/μR 抑制针对 T 独立抗原的体液免疫反应
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [A Shibuya, C Nakahashi, N Totsuka, S Tahara-Hanaoka., Honda S. et.al.]
通讯作者: Honda S. et.al.
43
    Development of the molecular targeted therapy for the chronic rejection after renal transplantation that control immunological memory
    • 批准号:
      26670575
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2014
    • 负责人:
      SHIBUYA Kazuko
    • 依托单位:
    Development of the molecular targeted therapy for allergic dermatitis
    • 批准号:
      25293091
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.07万
    • 财政年份:
      2013
    • 负责人:
      SHIBUYA Kazuko
    • 依托单位:
    Development of the novel molecular target therapy for the graft versus host disease (GVHD) using the humanized mice
    • 批准号:
      24659176
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      SHIBUYA Kazuko
    • 依托单位:
    Development of a novel tumor immunotherapy that targets the soluble poliovirus receptor
    • 批准号:
      22390073
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.9万
    • 财政年份:
      2010
    • 负责人:
      SHIBUYA Kazuko
    • 依托单位:
    海外基金