Molecular mechanisms for affinity-based selection, development and maintenance of memory B cells.

阐明记忆B细胞发育和维持的分子机制对于发展有效的疫苗接种和保护性免疫具有重要意义。在免疫应答中，与抗原高亲和力结合的B细胞在外周淋巴组织的生发中心被挑选出来，发育成记忆性B细胞，并维持很长一段时间，其机制在很大程度上尚不清楚。在这项研究中，我们利用诱导生发中心B(IGB)细胞培养系统，并确定了参与记忆B细胞发育和维持的候选因素。

Elucidation of molecular mechanisms for development and maintenance of memory B cells is important for development of efficient vaccination and protective immunity. During immune responses, B cells that bind antigens with a high affinity are selected in the germinal centers of peripheral lymphoid tissues, develop into memory B cells, and maintained for a long time, mechanisms for which have largely been unknown. In this study, we utilized the induced germinal center B (iGB) cell culture system, and identified candidates for the factors involved in the development and maintenance of memory B cells.