RNA Biology for Stress Assessment and Prediction of Major Depression

RNA 生物学用于压力评估和重度抑郁症预测

• 批准号: 22390146
• 负责人: ROKUTAN Kazuhito
• 金额: $ 11.98万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390146/
• 关键词: ストレス; うつ病; 遺伝子発現; RNAマーカー; マイクロRNA

This research project was designed to identify novel RNA markers for stress assessment and prediction of major depressive disorders. We reported acute stress-specific alternative splicing of SMG-1in peripheral blood (Neurosci Lett 2010) and chronic stress-specific reduction of a GR-beta isoform (Stress 2011). We also investigated stress-responsive microRNAs (miRNAs) in peripheral blood. We reported miR-16, miR-144, and miR144* as acute stress-responsive miRNAs (nuerosci Lett 2012).We also identified 7 miRNAs as chronic stress-responsive miRNAs.

该研究项目旨在鉴定用于压力评估和重度抑郁症预测的新型 RNA 标记。我们报道了外周血中 SMG-1 的急性应激特异性选择性剪接 (Neurosci Lett 2010) 和 GR-β 同种型的慢性应激特异性减少 (Stress 2011)。我们还研究了外周血中的应激反应性 microRNA (miRNA)。我们报告了 miR-16、miR-144 和 miR144* 作为急性应激反应 miRNA (nuerosci Lett 2012)。我们还鉴定了 7 个 miRNA 作为慢性应激反应 miRNA。

项目成果

Autism-associated gene expression in peripheral leucocytes commonly observed between subjects with autism and healthy women having autistic children.

• DOI: 10.1371/journal.pone.0024723
• 发表时间: 2011
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kuwano Y;Kamio Y;Kawai T;Katsuura S;Inada N;Takaki A;Rokutan K
• 通讯作者: Rokutan K

High-throughput screening of brief naturalistic stress-responsive cytokines in Japanese university students taking examinations

日本大学生考试中短暂自然应激反应细胞因子的高通量筛选

• 发表时间: 2010
• 作者: Mizukoshi E;Nakamoto Y;Araik;Yamashita T;et al.;Kazuhito Rokutan
• 通讯作者: Kazuhito Rokutan

遺伝子発現解析からみた慢性疲労症候群の病態

从基因表达分析看慢性疲劳综合征的病理学

• 发表时间: 2011
• 作者: Mizukoshi E;Nakamoto Y;Arai K;Yamashita T;Mukaida N;Matsushima K;Matsui O,Kaneko S;六反一仁
• 通讯作者: 六反一仁

Chronic inhibition of tumor cell-derived VEGF enhances the malignant phenotype of colorectal cancer cells.

• DOI: 10.1186/1471-2407-13-229
• 发表时间: 2013-05-07
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Yamagishi N;Teshima-Kondo S;Masuda K;Nishida K;Kuwano Y;Dang DT;Dang LH;Nikawa T;Rokutan K
• 通讯作者: Rokutan K

Ets1 and heat shock factor 1 regulate transcription of the Transformer 2beta gene in human colon cancer cell

Ets1和热休克因子1调节人结肠癌细胞中Transformer 2beta基因的转录

• 发表时间: 2013
• 期刊: J Gastroenterol
• 影响因子: 6.3
• 作者: Kajita K;Kuwano Y;Kitamura N;Satake Y;Nishida K;Kurokawa K;Akaike Y;Honda M;Masuda K;Rokutan K
• 通讯作者: Rokutan K