Research of innovative development of antagomirs regulating inflammation-associated carcinogenesis in hepatic microenvironment

目前的研究旨在开发抗配子体，抗microRNA寡核苷酸，调节肝脏微环境中的炎症相关癌变。在一个独特的慢性乙型肝炎小鼠模型中，对8个microRNAs在肝组织系列样本中的表达谱、细胞系的转化、对宿主基因表达的影响以及与肝癌发生过程中基因表达谱的关系进行了评估。总之，这些微小的RNA被认为是发展肝细胞癌抗配子体的靶点。

The current study was designed to develop antagomirs, anti-microRNA oligonucleotides, regulating inflammation-associated carcinogenesis in hepatic microenvironment. Eight of microRNAs identified in a unique mouse model of chronic hepatitis B were evaluated for the expression profiles in the serial samples of liver tissues, the transformation of cell lines, the effects on expression of host genes, the relation to gene expression profiles during hepatocarcinogenesis. Collectively, these microRNAswere suggested to be targets in the development of antagomirs for hepatocellular carcinoma.