Regeneration of Fibrotic Liver through Modulation of Hepatic Stem Cell Niche and Differentiation of Bone Marrow Stem Cells

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Liver is considered to have a high potential of regeneration, but the presence of fibrosis suppresses the recovery of injured liver. Stem cells are utilized to compensate such impaired regeneration. We have been working on the Notch/Jagged-1 signal to link liver fibrosis and stem cell mobilization. Experiments using Jagged-1 knockout mice have revealed important roles of the signal in the development of normal liver as well as the regeneration of fibrotic liver. These results may eventually contribute to the development of a novel therapeutic strategy that suppresses liver fibrosis and accelerate regeneration of fibrotic liver.