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Research on the association of GIP and metabolic diseases

Research on the association of GIP and metabolic diseases
GIP与代谢性疾病的关联性研究
批准号:
22390183
负责人:
YAMADA Yuichiro
金额:
$11.4万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

项目摘要

项目成果

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中文摘要
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英文摘要
GIP is one of the gut hormones, which stimulate insulin secretion from pancreatic β-cells after meal ingestion as an incretin. GIP receptor is expressed in various tissues, in addition to pancreaticβ-cells, and GIP is expected to play a several physiological role in vivo. We have shown that GIP receptor is expressed in stromal vascular fraction cells, in addition to adipocytes and that GIP regulates function of adipose tissues. GLP-1, the other incretin, has its proper function and α-glucosidase inhibitor can modulate the function of incretin through modulating the carbohydrate absorption from the gut.
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会议论文
DOI: 10.1038/hr.2011.127
发表时间: 2011-12-01
期刊: HYPERTENSION RESEARCH
影响因子: 5.4
作者: [Fujita, Hiroki, Sakamoto, Takuya, Yamada, Yuichiro]
通讯作者: Yamada, Yuichiro
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Matsuoka T, Suzuki SO, Iwaki T, Tabira T, Ordinario AT, Kira J, Yamada Y]
通讯作者: Yamada Y
DOI: 10.1038/hr.2011.176
发表时间: 2012-02
期刊: HYPERTENSION RESEARCH
影响因子: 5.4
作者: [Fujita, Hiroki, Fujishima, Hiromi, Morii, Tsukasa, Sakamoto, Takuya, Komatsu, Koga, Hosoba, Mihoko, Narita, Takuma, Takahashi, Keiko, Takahashi, Takamune, Yamada, Yuichiro]
通讯作者: Yamada, Yuichiro
Phenotypical variety of insulin resistance in a family with a novel mutation of the insulin receptor gene
胰岛素受体基因新突变家族中胰岛素抵抗的表型多样性
DOI: --
发表时间: 2010
期刊: Endocr J
影响因子: 2
作者: [Takahashi I, Yamada Y, Kadowaki H, Horikoshi M, Kadowaki T, Narita T, Tsuchida S, Noguchi A, Koizumi A, Takahashi T]
通讯作者: Takahashi T
Binding of sperm and oocyte induced by gut factor: Novel strategy for treatment of male infertility
  • 批准号:
    25670692
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.41万
  • 财政年份:
    2013
  • 负责人:
    YAMADA Yuichiro
  • 依托单位:
Studies on feeding selectivity of neritic copepods to toxic dinoflagellates
  • 批准号:
    21780183
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $1.83万
  • 财政年份:
    2009
  • 负责人:
    YAMADA Yuichiro
  • 依托单位:
Study on insulinoropic mechanisms co-operated by GLP-1 and GIP
  • 批准号:
    19591032
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.91万
  • 财政年份:
    2007
  • 负责人:
    YAMADA Yuichiro
  • 依托单位:
Study on metabolism in vivo mediated by gut hormone
  • 批准号:
    16500508
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.37万
  • 财政年份:
    2004
  • 负责人:
    YAMADA Yuichiro
  • 依托单位:
海外基金