Research on the association of GIP and metabolic diseases

GIP与代谢性疾病的关联性研究

• 批准号: 22390183
• 负责人: YAMADA Yuichiro
• 金额: $ 11.4万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390183/
• 关键词: 糖尿病; 栄養学; 生理活性; インクレチン

GIP is one of the gut hormones, which stimulate insulin secretion from pancreatic β-cells after meal ingestion as an incretin. GIP receptor is expressed in various tissues, in addition to pancreaticβ-cells, and GIP is expected to play a several physiological role in vivo. We have shown that GIP receptor is expressed in stromal vascular fraction cells, in addition to adipocytes and that GIP regulates function of adipose tissues. GLP-1, the other incretin, has its proper function and α-glucosidase inhibitor can modulate the function of incretin through modulating the carbohydrate absorption from the gut.

GIP是肠道激素之一，其作为肠促胰岛素在进食后刺激胰腺β细胞分泌胰岛素。GIP受体在除胰腺β细胞外的多种组织中表达，并且预期GIP在体内发挥多种生理作用。我们已经表明，GIP受体表达在基质血管组分细胞，除了脂肪细胞和GIP调节脂肪组织的功能。GLP-1是另一种肠促胰岛素，具有其自身的功能，α-葡萄糖苷酶抑制剂可通过调节肠道对碳水化合物的吸收来调节肠促胰岛素的功能。

项目成果

Reduction of circulating superoxide dismutase activity in type 2 diabetic patients with microalbuminuria and its modulation by telmisartan therapy

• DOI: 10.1038/hr.2011.127
• 发表时间: 2011-12-01
• 期刊: HYPERTENSION RESEARCH
• 影响因子: 5.4
• 作者: Fujita, Hiroki;Sakamoto, Takuya;Yamada, Yuichiro
• 通讯作者: Yamada, Yuichiro

Mass spectrometry-based simultaneous quantification of gastric inhibitory polypeptides GIP1-42 and GIP3-42 in human plasma

基于质谱法同时定量人血浆中胃抑制多肽 GIP1-42 和 GIP3-42

• 发表时间: 2012
• 作者: Matsuoka T;Suzuki SO;Iwaki T;Tabira T;Ordinario AT;Kira J;Yamada Y
• 通讯作者: Yamada Y

Modulation of renal superoxide dismutase by telmisartan therapy in C57BL/6-Ins2(Akita) diabetic mice.

• DOI: 10.1038/hr.2011.176
• 发表时间: 2012-02
• 期刊: HYPERTENSION RESEARCH
• 影响因子: 5.4
• 作者: Fujita, Hiroki;Fujishima, Hiromi;Morii, Tsukasa;Sakamoto, Takuya;Komatsu, Koga;Hosoba, Mihoko;Narita, Takuma;Takahashi, Keiko;Takahashi, Takamune;Yamada, Yuichiro
• 通讯作者: Yamada, Yuichiro

Phenotypical variety of insulin resistance in a family with a novel mutation of the insulin receptor gene

胰岛素受体基因新突变家族中胰岛素抵抗的表型多样性

• 发表时间: 2010
• 期刊: Endocr J
• 影响因子: 2
• 作者: Takahashi I;Yamada Y;Kadowaki H;Horikoshi M;Kadowaki T;Narita T;Tsuchida S;Noguchi A;Koizumi A;Takahashi T
• 通讯作者: Takahashi T