Study on the endoplasmic stress induced by oxsterol ester and its implication to diseases
Study on the endoplasmic stress induced by oxsterol ester and its implication to diseases
批准号:
22390187
负责人:
ISHIBASHI Shun
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
NCEH1是一种微粒体蛋白,可水解胆固醇酯(CE),介导羟胆固醇(25-HC)的酯化形式的水解。在人单核细胞来源的巨噬细胞中,NCEH1负责CE的水解。没有
英文摘要
NCEH1、an microsomal protein which hydrolizes cholesterol ester (CE), mediates the hydrolysis of esterified form of 25-hydroxycholesterol (25-HC), one of oxysterols. In human monocyte-derived macrophages, NCEH1 is responsible for the CE hydrolysis. Absence
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In vivo efficacy of PRD017, a new pyripyropene A derivative and highly potent ACAT2-selective inhibitor, in apolipoprotein E KO mice
PRD017(一种新型吡啶平 A 衍生物和高效 ACAT2 选择性抑制剂)在载脂蛋白 E KO 小鼠中的体内功效
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[豊田健太郎, 稲垣暢也, 曽根三郎, Ohshiro T]
通讯作者:
Ohshiro T
DOI:
10.1161/circresaha.110.226613
发表时间:
2010-11-26
期刊:
CIRCULATION RESEARCH
影响因子:
20.1
作者:
[Igarashi, Masaki, Osuga, Jun-ichi, Ishibashi, Shun]
通讯作者:
Ishibashi, Shun
DOI:
10.1016/j.bbrc.2010.11.103
发表时间:
2011-01-07
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Ohta, Keisuke, Sekiya, Motohiro, Osuga, Jun-ichi]
通讯作者:
Osuga, Jun-ichi
DOI:
10.5551/jat.6478
发表时间:
2011-01-01
期刊:
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
影响因子:
4.4
作者:
[Nagashima, Shuichi, Yagyu, Hiroaki, Ishibashi, Shun]
通讯作者:
Ishibashi, Shun
Depot-Specific Expression of Lipolytic Genes in Human Adipose Tissues.
人类脂肪组织中脂解基因的库特异性表达。
DOI:
--
发表时间:
2011
期刊:
J Atheroscler Thromb.
影响因子:
--
作者:
[Itoh Y, Toriumi H, Yamada S, Hoshino H, Suzuki N, Nagashima S]
通讯作者:
Nagashima S
共 7 条
Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in mice
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批准号:17390266
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.84万
-
财政年份:2005
-
负责人:ISHIBASHI Shun
-
依托单位:
New therapeutic targets for atherosclerotic plaques - The role of acyl CoA : cholesterol acyltransferase and neutral cholesterol ester hydrolase in foam cell formation
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批准号:12557092
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.51万
-
财政年份:2000
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负责人:ISHIBASHI Shun
-
依托单位:
Transgenic study on the heterogeneity of intacellular triacylglycerol lipase
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批准号:11470232
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$9.54万
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财政年份:1999
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负责人:ISHIBASHI Shun
-
依托单位:
Development of a novel animal model to investigate the role of cholesterol metabolism in the development and differentiation
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批准号:10557104
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.7万
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财政年份:1998
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负责人:ISHIBASHI Shun
-
依托单位:
Development of basic techniques for the liver-directed gene therapy
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批准号:07557071
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$9.47万
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财政年份:1995
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负责人:ISHIBASHI Shun
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依托单位:
海外基金