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Study on the endoplasmic stress induced by oxsterol ester and its implication to diseases

Study on the endoplasmic stress induced by oxsterol ester and its implication to diseases
氧甾醇酯诱导的内质应激及其疾病意义的研究
批准号:
22390187
负责人:
ISHIBASHI Shun
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

项目摘要

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中文摘要
翻译
NCEH 1是一种水解胆固醇酯(CE)的微粒体蛋白,介导酯化形式的25-羟基胆固醇(25-HC)(氧化甾醇之一)的水解。在人单核细胞衍生的巨噬细胞中,NCEH 1负责CE水解。没有
英文摘要
NCEH1、an microsomal protein which hydrolizes cholesterol ester (CE), mediates the hydrolysis of esterified form of 25-hydroxycholesterol (25-HC), one of oxysterols. In human monocyte-derived macrophages, NCEH1 is responsible for the CE hydrolysis. Absence
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会议论文
In vivo efficacy of PRD017, a new pyripyropene A derivative and highly potent ACAT2-selective inhibitor, in apolipoprotein E KO mice
PRD017(一种新型吡啶平 A 衍生物和高效 ACAT2 选择性抑制剂)在载脂蛋白 E KO 小鼠中的体内功效
DOI: --
发表时间:
期刊:
影响因子: --
作者: [豊田健太郎, 稲垣暢也, 曽根三郎, Ohshiro T]
通讯作者: Ohshiro T
DOI: 10.1161/circresaha.110.226613
发表时间: 2010-11-26
期刊: CIRCULATION RESEARCH
影响因子: 20.1
作者: [Igarashi, Masaki, Osuga, Jun-ichi, Ishibashi, Shun]
通讯作者: Ishibashi, Shun
DOI: 10.1016/j.bbrc.2010.11.103
发表时间: 2011-01-07
期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子: 3.1
作者: [Ohta, Keisuke, Sekiya, Motohiro, Osuga, Jun-ichi]
通讯作者: Osuga, Jun-ichi
DOI: 10.5551/jat.6478
发表时间: 2011-01-01
期刊: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
影响因子: 4.4
作者: [Nagashima, Shuichi, Yagyu, Hiroaki, Ishibashi, Shun]
通讯作者: Ishibashi, Shun
7
    Elucidation of novel functions of cholesterol and its metabolites using genetic manipulation in mice
    • 批准号:
      17390266
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.84万
    • 财政年份:
      2005
    • 负责人:
      ISHIBASHI Shun
    • 依托单位:
    New therapeutic targets for atherosclerotic plaques - The role of acyl CoA : cholesterol acyltransferase and neutral cholesterol ester hydrolase in foam cell formation
    • 批准号:
      12557092
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.51万
    • 财政年份:
      2000
    • 负责人:
      ISHIBASHI Shun
    • 依托单位:
    Transgenic study on the heterogeneity of intacellular triacylglycerol lipase
    • 批准号:
      11470232
    • 项目类别:
      Grant-in-Aid for Scientific Research (B).
    • 资助金额:
      $9.54万
    • 财政年份:
      1999
    • 负责人:
      ISHIBASHI Shun
    • 依托单位:
    Development of a novel animal model to investigate the role of cholesterol metabolism in the development and differentiation
    • 批准号:
      10557104
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.7万
    • 财政年份:
      1998
    • 负责人:
      ISHIBASHI Shun
    • 依托单位:
    海外基金