Basic research aimed at understanding and overcoming of the primary and secondary resistance in molecular target therapy

旨在了解和克服分子靶向治疗中原发性和继发性耐药的基础研究

• 批准号: 22390192
• 负责人: NAOE Tomoki
• 金额: $ 11.98万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390192/
• 关键词: 分子標的治療; 残存; 耐性; がん薬物治療; キナーゼ阻害剤

Although the outcome of patients with hematopoietic malignancies is significantly improved by using molecular target therapies, residual tumors and/or acquired resistance have become contemporary issues in the clinical field. In this study

尽管分子靶向治疗显著改善了恶性血液病患者的预后，但残留肿瘤和/或获得性耐药已成为临床领域的当代问题。在这项研究中

项目成果

Usefulness of Peripheral Blood Circulating DNAs As an Alternative to DNA From Bone Marrow Cells to Detect CpG Global Methylation Status and Genetic Mutations in Patients with Myelodysplastic Syndromes

外周血循环 DNA 作为骨髓细胞 DNA 替代品检测骨髓增生异常综合征患者 CpG 整体甲基化状态和基因突变的有用性

• 发表时间: 2012
• 作者: Iriyama C;Tomita A;Naoe T,et al
• 通讯作者: Naoe T,et al

Wnt signaling is associated with anti-apoptosis in the interaction between acute myeloid leukemia cells and stromal cells

Wnt信号传导与急性髓系白血病细胞和基质细胞相互作用中的抗凋亡相关

• 发表时间: 2012
• 作者: Minami Y;Naoe T;et al
• 通讯作者: et al

A Novel STAT3 Inhibitor OPB-31121 Induces Tumor-Specific Growth Inhibition in a Wide Range of Hematopoietic Malignancies without Growth Suppression of Normal Hematopoietic Cells

新型 STAT3 抑制剂 OPB-31121 可在多种造血恶性肿瘤中诱导肿瘤特异性生长抑制，而不抑制正常造血细胞的生长

• 发表时间: 2011
• 作者: Hayakawa F;Naoe T,et al
• 通讯作者: Naoe T,et al

CD20 Protein Immunohistochemistry-Positive/Flow Cytometry-Negative Diffuse Large B-Cell Lymphoma-Analyses of the Molecular Mechanisms and Rituximab Effectiveness

CD20 蛋白免疫组织化学-阳性/流式细胞术-阴性弥漫性大 B 细胞淋巴瘤-分子机制和利妥昔单抗有效性分析

• 发表时间: 2011
• 作者: Tokunaga T;Naoe T,et al
• 通讯作者: Naoe T,et al

Y654 of β-catenin is essential for FLT3/ITD-related tyrosine phosphorylation and nuclear localization of β-catenin

• DOI: 10.1111/j.1600-0609.2011.01738.x
• 发表时间: 2012-04-01
• 期刊: EUROPEAN JOURNAL OF HAEMATOLOGY
• 影响因子: 3.1
• 作者: Kajiguchi, Tomohiro;Katsumi, Akira;Naoe, Tomoki
• 通讯作者: Naoe, Tomoki