Physiological role of maternal-fetal LIF signal relay in the development of cerebral cortex

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Leukemia inhibitory factor (LIF) induces adrenocorticotropic hormone (ACTH) from the placenta, which in turn induces fetal nucleated red blood cells to secrete LIF. In the present study, it was revealed that fetal LIF induces insulin-like growth factor 1 or 2 that increases neurogenesis in the developing rat cerebrum. In addition, it was revealed that placental ACTH contributes to the differentiation of fetal erythroblasts. These findings suggest that the development of brain and red blood cells is regulated synchronously by maternal-fetalLIF signal relay.