Maternal leukemia inhibitory factor regulates fetal brain development via a maternal-fetal signaling pathway
Maternal leukemia inhibitory factor regulates fetal brain development via a maternal-fetal signaling pathway
批准号:
19390291
负责人:
HATTA Toshihisa
金额:
$12.15万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
Placental trophoblasts in rats are stimulated by maternal leukemia inhibitory factor (LIF) to secrete adrenocorticotropic hormone (ACTH) into the fetal blood circulation. Then, fetal nucleated red blood cells are reactive to placental ACTH to secrete LIF, which induces an increase of LIF level in the fetal cerebrospinal fluid. Finally, the neuron production in the fetal forebrain increased.
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Congenital deformities and developmental abnormalities of the mandibular condyle in the temporomandibular foint.
颞下颌关节内下颌髁突先天性畸形和发育异常。
DOI:
--
发表时间:
2008
期刊:
Congenit. Anom. (Kyoto) 48
影响因子:
--
作者:
[Dai, X. Sayama, K. Shirakata, Y. Tokumaru, S. YangL. Tohyama, M. Hirakawa, S. Hanakawa, Y., Hashimoto, K., K. Kaneyame]
通讯作者:
K. Kaneyame
Quantitative Analysis of Delayed Neuronal Death in the Hippocampal Subfields of SHRP and SHR
SHRP 和 SHR 海马亚区迟发性神经元死亡的定量分析
DOI:
--
发表时间:
2009
期刊:
Cell Mol Neurobiol 29
影响因子:
--
作者:
[Daisu M, Hatta T, Sakurai-Yamashita Y, Nabika T, Moritake K]
通讯作者:
Moritake K
Quantitative analysis of delayed neuronal death in the hippocampal subfields of SHRSP and SHR
SHRSP和SHR海马亚区迟发性神经元死亡的定量分析
DOI:
--
发表时间:
2009
期刊:
Cell Mol Neurobiol 29
影响因子:
--
作者:
[坂田(柳元)麻実子, 他, 富田博秋, T Hatta]
通讯作者:
T Hatta
Adrenocorticotropic hormone affects nonapoptotic cell death of undifferentiated germ cells in fetal mouse testis.:In vivo study by exo utero transplantation of corticotropic tumor cells into embryos
促肾上腺皮质激素影响胎儿小鼠睾丸中未分化生殖细胞的非凋亡细胞死亡。:促肾上腺皮质肿瘤细胞宫外移植到胚胎的体内研究
DOI:
--
发表时间:
2008
期刊:
Congenital Anomalies 48(2)
影响因子:
--
作者:
[Nimura M, Udagawa J, Otani H]
通讯作者:
Otani H
Development of the brain as an integral part of harmonized systemic histogenesis.
大脑的发育是协调的系统组织发生的一个组成部分。
DOI:
--
发表时间:
2008
期刊:
J Brain Science (In press)
影响因子:
--
作者:
[Sayama K, Shirakata Y, Ishimatsu-Tsuji Y, Kajiya K, Hirakawa S, Sugawara K, Chambon P, Akira S, Paus R, Kishimoto J, Hashimoto K., Otani H]
通讯作者:
Otani H
共 48 条
Development of an ultra-high-speed brain scanner for comprehensive imaging of the entire human brain
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批准号:19K22696
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项目类别:Grant-in-Aid for Challenging Research (Exploratory)
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资助金额:$3.99万
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财政年份:2019
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负责人:HATTA Toshihisa
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依托单位:
Mechanism of induction of inter neuron production in fetal cerebral cortex by maternal-fetal signal relay
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批准号:16H05364
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.23万
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财政年份:2016
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负责人:HATTA Toshihisa
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依托单位:
Structural analysis of maternal-fetal signal transmitter
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批准号:15K15405
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2015
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负责人:HATTA Toshihisa
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依托单位:
The signal tuning system for the maternal-fetal signal relay
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批准号:25293241
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
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财政年份:2013
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负责人:HATTA Toshihisa
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依托单位:
Prenatal origin of the risk of mental disorders caused by the defects of maternal-fetal signal relay
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批准号:24659512
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2012
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负责人:HATTA Toshihisa
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依托单位:
Physiological role of maternal-fetal LIF signal relay in the development of cerebral cortex
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批准号:22390216
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$12.15万
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财政年份:2010
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负责人:HATTA Toshihisa
-
依托单位:
海外基金